Syndecans in tumor cell adhesion and signaling

被引：195

作者：

Beauvais D.M. ^{[1
]}

Rapraeger A.C. ^{[1
]}

机构：

[1] Dept. of Pathol./Laboratory Medicine, 6459 Medical Sciences Center, University of Wisconsin-Madison, Madison, WI 53706-1510

来源：

Reproductive Biology and Endocrinology | / 2卷 / 1期

关键词：

Focal Adhesion Kinase; Focal Adhesion; Heparan Sulfate; Cell Spreading; Malignant Mesothelioma;

D O I：

10.1186/1477-7827-2-3

中图分类号：

学科分类号：

摘要：

Anchorage of cells to "heparin"-binding domains that are prevalent in extracellular matrix (ECM) components is thought to occur primarily through the syndecans, a four-member family of transmembrane heparan sulfate proteoglycans that communicate environmental cues from the ECM to the cytoskeleton and the signaling apparatus of the cell. Known activities of the syndecans trace to their highly conserved cytoplasmic domains and to their heparan sulfate chains, which can serve to regulate the signaling of growth factors and morphogens. However, several emerging studies point to critical roles for the syndecans' extracellular protein domains in tumor cell behavior to include cell adhesion and invasion. Although the mechanisms of these activities remain largely unknown, one possibility involves"co-receptor" interactions with integrins that may regulate integrin function and the cell adhesion-signaling phenotype. Thus, alterations in syndecan expression, leading to either overexpression or loss of expression, boh of which take place in tumor cells, may have dramatic effects on tumor cell invasion. © 2004 Beauvais and Rapraeger; licensee BioMed Central Ltd.

引用

页数：12

共 123 条

[1] Brooks P.C., Montgomery A.M., Rosenfeld M., Reisfeld R.A., Hu T., Klier G., Cheresh D.A., Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels, Cell, 79, pp. 1157-1164, (1994)
[2] Domanico S.Z., Pelletier A.J., Havran W.L., Quaranta V., Integrin alpha 6A beta 1 induces CD81-dependent cell motility without engaging the extracellular matrix migration substrate, Mol. Biol. Cell, 8, pp. 2253-2265, (1997)
[3] Brassard D.L., Maxwell E., Malkowski M., Nagabhushan T.L., Kumar C.C., Armstrong L., Integrin alpha(v)beta(3)-mediated activation of apoptosis, Exp. Cell Res., 251, pp. 33-45, (1999)
[4] Kuzuya M., Satake S., Ramos M.A., Kanda S., Koike T., Yoshino K., Ikeda S., Iguchi A., Induction of apoptotic cell death in vascular endothelial cells cultured in three-dimensional collagen lattice, Exp. Cell Res., 248, pp. 498-508, (1999)
[5] Stupack D.G., Puente X.S., Boutsaboualoy S., Storgard C.M., Cheresh D.A., Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins, J. Cell Biol., 155, pp. 459-470, (2001)
[6] Bachelder R.E., Marchetti A., Falcioni R., Soddu S., Mercurio A.M., Activation of p53 function in carcinoma cells by the alpha6beta4 integrin, J. Biol. Chem., 274, pp. 20733-20737, (1999)
[7] Lewis J.M., Truong T.N., Schwartz M.A., Integrins regulate the apoptotic response to DNA damage through modulation of p53, Proc. Natl. Acad. Sci. U. S. A., 99, pp. 3627-3632, (2002)
[8] Iba K., Albrechtsen R., Gilpin B., Frohlich C., Loechel F., Zolkiewska A., Ishiguro K., Kojima T., Liu W., Langford J.K., Sanderson R.D., Brakebusch C., Fassler R., Wewer U.M., The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading, J. Cell Biol., 149, pp. 1143-1156, (2000)
[9] Thodeti C.K., Albrechtsen R., Grauslund M., Asmar M., Larsson C., Takada Y., Mercurio A.M., Couchman J.R., Wewer U.M., ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA, J. Biol. Chem., 278, pp. 9576-9584, (2003)
[10] Ly D.P., Zazzali K.M., Corbett S.A., De Novo Expression of the Integrin {alpha}5{beta}1 Regulates {alpha}v{beta}3-mediated Adhesion and Migration on Fibrinogen, J. Biol. Chem., 278, pp. 21878-21885, (2003)

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