Endometrial hormone receptors in women with dysfunctional uterine bleeding

被引：18

作者：

Chakraborty S. ^{[1
,2
]}

Khurana N. ^{[1
]}

Sharma J.B. ^{[3
]}

Chaturvedi K.U. ^{[1
]}

机构：

[1] Department of Histopathology, Maulana Azad Medical College

[2] 110075 Dwarka, New Delhi, 153

[3] Department of Gynecology and Obstetrics, All India Institute of Medical Sciences, New Delhi

来源：

Archives of Gynecology and Obstetrics | 2005年 / 272卷 / 1期

关键词：

Dysfunctional uterine bleeding (DUB); Estrogen receptor (ER); Progesterone receptor (PR);

D O I：

10.1007/s00404-004-0639-5

中图分类号：

学科分类号：

摘要：

Objective: The objective was to study the estrogen receptor (ER) and progesterone receptor (PR) expression in endometrium of women with dysfunctional uterine bleeding (DUB) as compared to women with normal menstrual cycles. Methods: In this study, 30 patients and 20 controls were selected. Transvaginal ultrasound and endometrial sampling for histology and ER and PR estimation immunohistochemically was carried out for all the subjects. Student's t-test and linear correlation was used for statistical analysis. Their response to treatment was assessed by clinical follow-up. Results: Endometrial thickness and ER and PR levels in DUB patients were significantly higher. In cases showing hyperplastic endometria, ER and PR levels were higher than patients with normal histology. In contrast to hyperplastic tissue, steroid receptor levels decrease in hyperplastic tissue containing atypia. Conclusion: Altered endometrial morphology and increased receptor levels in DUB patients suggest that unopposed estrogen effect could have an important role in the pathogenesis of DUB. Cases of DUB, which showed atypical hyperplasia, may have a down-regulation of these receptors and could be a precursor lesion to carcinoma and thus do not respond to medical therapy by hormones. © Springer-Verlag 2004.

引用

页码：17 / 22

页数：5

共 20 条

[1]

Bancroft J.D., Stevens A., Theory and Practice of Histological Techniques, 4th Edn., (1996)

[2]

Bergeron C., Ferenczy A., Shyamala G., Distribution of estrogen receptors in various cell types of normal, hyperplastic and neoplastic human endometrial tissues, Lab Invest, 59, pp. 862-869, (1988)

[3]

Chwalisz K., Brenner R.M., Fuhrmann U.U., Hess-Stumpp H., Elger W., Antiproliferative effects of progesterone antagonists and progesterone receptor modulators on endometrium, Steroids, 65, pp. 741-751, (2000)

[4]

Critchley H.O.D., Abberton K.M., Taylor N.H., Healy D.L., Rogers P.A.W., Endometrial sex steroid receptor expression in women with menorrhagia, Br J Obstet Gynecol, 101, pp. 428-434, (1994)

[5]

Davis J.T.A., Schlaff W.D., Dysfunctional uterine bleeding, polyps and fibroids, Infertility and Reproductive Medicine, 6, 2, pp. 401-415, (1995)

[6]

Gasier A.F., Wang H., Davie J.E., Kelly R.W., Critchley H.O., Administration of anti-progesterone upregulates estrogen receptors in endometrium of women using Norplant: A pilot study, Fertil Steril, 77, pp. 366-372, (2002)

[7]

Gleeson N., Jordan M., Sheppard B., Bonnar J., Clinical variation in endometrial estrogen and progesterone receptors in women with normal menstruation and dysfunctional uterine bleeding, Eur J Obstet Gynecol Reprod Biol, 48, pp. 207-214, (1993)

[8]

Gorodeski I.G., Geier A., Siegal A., Beery R., Lunenfeld B., Langzam J., Bahari C.M., In vitro induction of progesterone receptors in normal postmenopausal endometrium - An evidence of inhibitory control of RP synthesis, Maturitas, 6, (1984)

[9]

Haynes P.J., Anderson A.B.M., Turnbull A.C., Patterns of menstrual blood loss in menorrhagia, Res Clin Forum, 1, pp. 73-78, (1979)

[10]

Leake R.E., Steroid receptors in normal and cancer tissue, Hormonal Management of Endocrine Related Cancer, pp. 3-12, (1981)

← 1 2 →