Regulation of smooth muscle phenotype

被引：49

作者：

Ichiro Manabe

Ryozo Nagai

机构：

[1] Dept. of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo 113-8655

来源：

Current Atherosclerosis Reports | 2003年 / 5卷 / 3期

关键词：

Serum Response Factor; Phenotypic Modulation; Smooth Muscle Myosin Heavy Chain; Smooth Muscle Differentiation; Smooth Muscle Cell Differentiation;

D O I：

10.1007/s11883-003-0027-9

中图分类号：

学科分类号：

摘要：

Differentiated smooth muscle cells (SMCs) remain highly plastic, enabling them to alter their phenotype in response to environmental and pathologic stimuli. SMCs in vascular pathologies such as atherosclerosis exhibit phenotypes clearly different from those of the mature cells in normal blood vessels. These phenotypically modulated SMCs play an integral role in the development of vascular diseases. This review addresses recent progress in our understanding of the mechanisms that control SMC phenotype during vascular development and in vascular disease. A particular focus is on the transcriptional control programs of the differentiated state of SMCs. Copyright © 2003 by Current Science Inc.

引用

页码：214 / 222

页数：8

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