The Regulation and Consequences of Immune-Mediated Cell Death in Atheromatous Diseases

被引：10

作者：

Jonathan C. Choy

Thomas J. Podor

Bobby Yanagawa

John C. K. Lai

David J. Granville

David C. Walker

Bruce M. McManus

机构：

[1] Dept. of Pathol. and Lab. Medicine, St. Paul's Hosp./Provid. Hlth. Care, University of British Columbia, Vancouver, BC

[2] McDonald Research Laboratories, iCAPTUR4E Centre, St. Paul's Hospital, Vancouver

来源：

Cardiovascular Toxicology | 2003年 / 3卷 / 3期

基金：

加拿大健康研究院;

关键词：

Apoptosis; Coronary artery disease; FasL; Granzyme B; T-cell; Transplant vascular disease;

D O I：

10.1385/CT:3:3:269

中图分类号：

学科分类号：

摘要：

Atheromatous diseases are lipid and cell-rich vascular disorders that include coronary artery disease (CAD), transplant vascular disease (TVD), and restenosis. Considering the inflammatory nature of these diseases, cytotoxic immune mechanisms such as the FasL and granzyme/perforin pathways most likely play important roles in the development and remodeling of many lesions. Furthermore, although the contributions of immune responses to each disease vary, the correspondent localization of certain mediators and effectors suggests that they may contribute to a spectrum of atheromatous diseases. In this review, the contribution of immune cell-mediated cell death in the onset and pathogenesis of CAD and TVD is examined.

引用

页码：269 / 282

页数：13

共 95 条

[1]

Ross R., Atherosclerosis: An inflammatory disease, N. Engl. J. Med., 340, pp. 115-126, (1999)

[2]

Wilson J.E., Wood S., McDonald P., Kenyon J., Dong C., McManus B.M., Contribution of lipids to the pathogenesis of transplant vascular sclerosis, Transpl. Immunol., 5, pp. 247-250, (1997)

[3]

McDonald P.C., Kenyon J.A., McManus B.M., The role of lipids in transplant vascular disease, Lab. Invest., 78, pp. 1187-1201, (1998)

[4]

Choy J.C., Granville D.J., Hunt D.W., McManus B.M., Endothelial cell apoptosis: Biochemical characteristics and potential implications for atherosclerosis, J. Mol. Cell. Cardiol., 33, pp. 1673-1690, (2001)

[5]

Kerr J.F.R., Wyllie A.H., Currie A.R., Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics, Br. J. Cancer., 26, pp. 239-245, (1972)

[6]

Granville D.J., Carthy C.M., Hunt D.W., McManus B.M., Apoptosis: Molecular aspects of cell death and disease, Lab. Invest., 78, pp. 893-913, (1998)

[7]

Caplan B.A., Schwartz C.J., Increased endothelial cell turnover in areas of in vivo Evans Blue uptake in the pig aorta, Atherosclerosis, 17, pp. 401-417, (1973)

[8]

Caplan B.A., Gerrity R.G., Schwartz C.J., Endothelial cell morphology in focal areas of in vivo Evans blue uptake in the young pig aorta. I. Quantitative light microscopic findings, Exp. Mol. Pathol., 21, pp. 102-117, (1974)

[9]

Somer J.B., Schwartz C.J., Focal 3 H-cholesterol uptake in the pig aorta, Atherosclerosis, 13, pp. 293-304, (1971)

[10]

Somer J.B., Schwartz C.J., Focal (3 H)cholesterol uptake in the pig aorta. 2. Distribution of (3 H)cholesterol across the aortic wall in areas of high and low uptake in vivo, Atherosclerosis, 16, pp. 377-388, (1972)

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