Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)

被引：231

作者：

Chao W-W. ^{[1
]}

Lin B.-F. ^{[1
]}

机构：

[1] Department of Biochemical Science and Technology, College of Life Science, National Taiwan University

来源：

Chinese Medicine | / 5卷 / 1期

关键词：

Nitric Oxide; Experimental Autoimmune Encephalomyelitis; Methanol Extract; Ethanol Extract; Mean Arterial Blood Pressure;

D O I：

10.1186/1749-8546-5-17

中图分类号：

学科分类号：

摘要：

Andrographis paniculata (Burm. f.) Nees (Acanthaceae) (A. paniculata, Chuanxinlian), native to Taiwan, Mainland China and India, is a medicinal herb with an extremely bitter taste used to treat liver disorders, bowel complaints of children, colic pain, common cold and upper respiratory tract infection 123. The aerial part of A. paniculata is commonly used in Chinese medicine. According to Chinese medicine theory, A. paniculata 'cools' and relieves internal heat, inflammation and pain and is used for detoxication 456. The herb contains diterpenoids, flavonoids and polyphenols as the major bioactive components 78. This article reviews the constituents and pharmacological properties of A. paniculata, including its chemical components, biological activities and possible mechanisms. The literature search was conducted in Pubmed database (1984-2010), focused on language literature in English. The keywords used were selected from andrographolide, A. paniculata and its compounds with bioactivities. In comparison with other Chinese medicinal herbs, this well studied herb not only shows a wide variety of health benefits, but many bioactive compounds are also being identified. Furthermore, several derivatives have been semi-synthesized to enhance their bioactivity than original compounds, suggesting a potential for drug development. The authors read more than 200 full articles and a total of 124 peer-reviewed papers focused on anti-inflammation, anti-cancer, immunomodulation, anti-infection, anti-hepatotoxicity, anti-atherosclerosis, anti-diabetes and anti-oxidation were selected for this review. © 2010 Chao and Lin; licensee BioMed Central Ltd.

引用

共 124 条

[1]

Negi A.S., Kumar J.K., Luqman S., Sbanker K., Gupta M.M., Kbanuja S.P.S., Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads, Med Res Rev, 28, 5, (2008)

[2]

Roxas M., Jurenka J., Colds and influenza: A review of diagnosis and conventional, botanical and nutritional considerations, Altern Med Rev, 12, pp. 25-48, (2007)

[3]

Kligler B., Ulbricht C., Basch E., Kirkwood C.D., Abrams T.R., Miranda M., Singh Khalsa K.P., Giles M., Boon H., Woods J., Andrographis paniculata for the treatment of upper respiratory infection: a systematic review by the natural standard research collaboration, Explore, 2, 1, pp. 25-29, (2006)

[4]

Huang C.J., Wu M.C., Differential effects of foods traditionally regarded as 'heating' and 'cooling' on prostaglandin E2 production by a macrophage cell line, J Biomed Sci, 9, pp. 596-606, (2002)

[5]

Chao W.W., Kuo Y.H., Li W.C., Lin B.F., The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractions, J Ethnopharmacol, 122, pp. 68-75, (2009)

[6]

Mandal S.C., Dhara A.K., Maiti B.C., Studies on Psychopharmacological Activity of Andrographis paniculata Extract, Phytother Res, 15, pp. 253-256, (2001)

[7]

Rao Y.K., Vimalamma G., Rao C.V., Tzeng Y., Flavonoids and andrographolides from Andrographis paniculata, Phytochemistry, 65, pp. 2317-2321, (2004)

[8]

Xu C., Chou G.X., Wang Z.T., A new diterpene from the leaves of Andrographis paniculata Nees, Fitoterapia, (2010)

[9]

Cheung H.Y., Cheung C.S., Kong C.K., Determination of bioactive diterpenoids from Andrographis paniculata by micellar electrokinetic chromatography, J Chromatogr A, 930, 1-2, pp. 171-176, (2001)

[10]

Matsuda T., Kuroyanagi M., Sugiyama S., Umehara K., Ueno A., Nishi K., Cell differentiation inducing diterpenes from Andrographis paniculata Nees, Chem Pharm Bull (Tokyo), 42, pp. 1216-1225, (1994)

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