Ocular involvement in nasal natural killer T-cell lymphoma

被引：29

作者：

Cimino L. ^{[1
]}

Chan C.-C. ^{[2
]}

Shen D.F. ^{[2
]}

Masini L. ^{[3
]}

Ilariucci F. ^{[3
]}

Masetti M. ^{[4
]}

Asioli S. ^{[5
]}

Sartori A. ^{[1
]}

Cappuccini L. ^{[1
]}

机构：

[1] Department of Ophthalmology, Arcispedale S.M. Nuova, 42100 Reggio Emilia

[2] Laboratory of Immunology, National Eye Institute, Bethesda, MD

[3] Department of Hematology, Arcispedale S.M. Nuova, 42100 Reggio Emilia

[4] Department of Otolaryngology, Arcispedale S.M. Nuova, 42100 Reggio Emilia

[5] Department of Pathology, Arcispedale S.M. Nuova, 42100 Reggio Emilia

来源：

International Ophthalmology | 2009年 / 29卷 / 4期

关键词：

Masquerade syndrome; Nasal type lymphoma; Natural killer T-cell lymphoma; Serous retinal detachment;

D O I：

10.1007/s10792-008-9220-8

中图分类号：

学科分类号：

摘要：

Purpose: To describe the clinical, morphologic, and immunohistochemical features of a case of paranasal natural killer/T-cell lymphoma (NKTL) with ocular involvement. Case report: In March 2005 the patient presented with a maxillary sinusitis and upper nasal obstruction. In July she underwent a nasal computed tomography (CT) scan and multiple biopsies of the granulomatous tissue in the nasal fossae. The diagnosis was NK/T non-Hodgkin's lymphoma nasal type, stage IV A. Afterwards she presented anterior uveitis. In September after the diagnosis of lymphoma the patient underwent a bone marrow biopsy and thoracic and abdominal CT scan. An ophthalmic examination including visual acuity assessment and fundoscopic examination was made. In October she started chemotherapy cycles. Maxillary CT scan and ophthalmic examinations were performed during the cycles. In January 2006 after severe recurrences of panuveitis a diagnostic vitrectomy was performed. Results: A diagnosis of T-lymphoma cells in the vitreous was made; the tumor was most likely originating from her paranasal NKTL. The condition of the patient deteriorated rapidly and she expired on February 2006. Conclusions: Nasal and paranasal sinus lymphomas are rare, but aggressive diseases with a tendency to invade tissues and spread to CNS, including the eye. Ocular manifestations prior to systemic ones may be useful to monitor the response to therapy. © Springer Science+Business Media B.V. 2008.

引用

页码：275 / 279

页数：4

共 21 条

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