Oxidative stress as determined by glutathione (GSH) concentrations in venous cord blood in elective cesarean delivery versus uncomplicated vaginal delivery

被引：38

作者：

Paamoni-Keren O. ^{[1
]}

Silberstein T. ^{[1
]}

Burg A. ^{[2
]}

Raz I. ^{[1
]}

Mazor M. ^{[1
]}

Saphier O. ^{[2
]}

机构：

[1] Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva

[2] Department Chemical Engineering, Faculty of Chemical Engineering, Sami Shamoon College of Engineering

来源：

Archives of Gynecology and Obstetrics | 2007年 / 276卷 / 1期

关键词：

Elective cesarean delivery; Glutathione; Oxidative stress; Uncomplicated vaginal delivery;

D O I：

10.1007/s00404-006-0304-2

中图分类号：

学科分类号：

摘要：

Objective: To determine whether neonates are subject to oxidative stress by the labor process and the mode of delivery by measuring glutathione (GSH) concentrations in umbilical cord venous blood. Study design: Forty-eight women with singleton term pregnancies were prospectively recruited and classified as follows: 26 women had a spontaneous uncomplicated vaginal delivery (VD), and 22 women had an elective cesarean delivery (CD). GSH concentration in umbilical venous blood samples was determined by a spectroscopic method. Results: Umbilical cord venous blood GSH levels were significantly lower in the elective CD group than in the VD group (2.2 and 2.7 mM, respectively, P = 0.0003). There was a significantly negative correlation between cord blood pO2 and GSH levels; however, the negative correlation was significantly higher in the elective CD group (P < 0.05). Conclusion: Neonates delivered by CD were exposed to a higher oxidative stress as determined by GSH levels compared to those who had an uncomplicated VD. © 2007 Springer-Verlag.

引用

页码：43 / 46

页数：3

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