Development of the retinal vasculature

被引：386

作者：

Fruttiger M. ^{[1
]}

机构：

[1] UCL Institute of Ophthalmology, London EC1V 9EL

来源：

Angiogenesis | 2007年 / 10卷 / 2期

基金：

英国医学研究理事会;

关键词：

Angiogenesis; Endothelial cells; Hyaloid vasculature; Neovascularization; Oxygen induced retinopathy; Retinal astrocytes; Vascular remodelling; Vasculogenesis; Vaso-obliteration; Vessel regression;

D O I：

10.1007/s10456-007-9065-1

中图分类号：

学科分类号：

摘要：

Blood vessels that supply the inner portion of the retina are extensively reorganized during development. The vessel regression, sprouting angiogenesis, vascular remodelling and vessel differentiation events involved critically depend on cell-cell signalling between different cellular components such as neurons, glia, endothelial cells, pericytes and immune cells. Studies in mice using transgenic and gene deletion approaches have started to unravel the genetic basis of some of these signalling pathways and have lead to a much improved understanding of the molecular mechanisms controlling retinal blood vessel behaviour both during development and under pathological conditions. Such insight will provide the basis of future therapeutic approaches aimed at manipulating retinal blood vessels. © 2007 Springer Science + Business Media B.V.

引用

页码：77 / 88

页数：11

共 124 条

[1]

Watanabe T., Raff M.C., Retinal astrocytes are immigrants from the optic nerve, Nature, 332, pp. 834-837, (1988)

[2]

Stone J., Dreher Z., Relationship between astrocytes, ganglion cells and vasculature of the retina, J Comp Neurol, 255, pp. 35-49, (1987)

[3]

Fruttiger M., Calver A.R., Kruger W.H., Mudhar H.S., Michalovich D., Takakura N., Nishikawa S., Richardson W.D., PDGF mediates a neuron-astrocyte interaction in the developing retina, Neuron, 17, pp. 1117-1131, (1996)

[4]

Ling T.L., Stone J., The development of astrocytes in the cat retina: Evidence of migration from the optic nerve, Brain Res, 44, pp. 73-85, (1988)

[5]

Schnitzer J., Retinal astrocytes: Their restriction to vascularized parts of the mammalian retina, Neurosci Lett, 78, pp. 29-34, (1987)

[6]

Huxlin K.R., Sefton A.J., Furby J.H., The origin and development of retinal astrocytes in the mouse, J Neurocytol, 21, pp. 530-544, (1992)

[7]

Engerman R.L., Development of the macular circulation, Invest Ophthalmol, 15, pp. 835-840, (1976)

[8]

Chu Y., Hughes S., Chan-Ling T., Differentiation and migration of astrocyte precursor cells and astrocytes in human fetal retina: Relevance to optic nerve coloboma, FASEB J, 15, pp. 2013-2015, (2001)

[9]

Mi H., Barres B.A., Purification and characterization of astrocyte precursor cells in the developing rat optic nerve, J Neurosci, 19, pp. 1049-1061, (1999)

[10]

Mudhar H.S., Pollock R.A., Wang C., Stiles C.D., Richardson W.D., PDGF and its receptors in the developing rodent retina and optic nerve, Development, 118, pp. 539-552, (1993)

← 1 2 3 4 5 6 7 8 9 10 →