Quantitative analysis of polyethylene wear debris, wear rate and head damage in retrieved Charnley hip prostheses

被引：38

作者：

Tipper J.L. ^{[1
]}

Ingham E. ^{[1
]}

Hailey J.L. ^{[2
]}

Besong A.A. ^{[2
]}

Fisher J. ^{[2
]}

Wroblewski B.M. ^{[3
]}

Stone M.H. ^{[4
]}

机构：

[1] Department of Microbiology, University of Leeds, Leeds

[2] Department of Mech. Engineering, University of Leeds, Leeds

[3] Centre for Hip Surgery, Wrightington Hospital, Wigan

[4] Department of Orthopaedic Surgery, General Infirmary, Leeds

来源：

Journal of Materials Science: Materials in Medicine | 2000年 / 11卷 / 02期

关键词：

Particle size analysis - Ultrahigh molecular weight polyethylenes - Wear of materials;

D O I：

10.1023/A:1008901302646

中图分类号：

学科分类号：

摘要：

Submicrometer- and micrometer-sized ultra-high molecular weight polyethylene (UHMWPE) wear particles have been associated with osteolysis and failure of total artificial joints. Previous studies have isolated predominantly submicrometer-sized particles at the expense of larger particles ( > 10 μm). This study aimed to isolate and characterize quantitatively all sizes of UHMWPE wear particles generated in 18 Charnley hip prostheses. In addition, to analyze the wear debris with respect to the total volumetric wear of the cup and damage to the femoral head. Particle size distributions ranged from 0.1 to - > 1000 μm. A significant proportion (3-82%) of the mass of the wear debris isolated was > 10 μm. The mode of the frequency distribution of the particles was in the range 0.1-0.5 μm for all patients. However, analysis of the mass of wear debris as a function of its size allowed differentiation of the wear debris from different patients. Femoral head damage was associated with high volumetric wear and increased numbers of biologically active submicrometer-sized particles. (C) 2000 Kluwer Academic Publishers.Submicrometer- and micrometer-sized ultra-high molecular weight polyethylene (UHMWPE) wear particles have been associated with osteolysis and failure of total artificial joints. Previous studies have isolated predominantly submicrometer-sized particles at the expense of larger particles (>10 μm). This study aimed to isolate and characterize quantitatively all sizes of UHMWPE wear particles generated in 18 Charnley hip prostheses. In addition, to analyze the wear debris with respect to the total volumetric wear of the cup and damage to the femoral head. Particle size distributions ranged from 0.1 to - >1000 μm. A significant proportion (3-82%) of the mass of the wear debris isolated was >10 μm. The mode of the frequency distribution of the particles was in the range 0.1-0.5 μm for all patients. However, analysis of the mass of wear debris as a function of its size allowed differentiation of the wear debris from different patients. Femoral head damage was associated with high volumetric wear and increased numbers of biologically active submicrometer-sized particles.

引用

页码：117 / 124

页数：7

共 18 条

[1]

Howie, D.W., Haynes, D.R., Rogers, S.D., McGee, M.A., Pearcy, M.J., (1993) Onthop. Clin. N. Amer., 24, p. 571

[2]

Jasty, M., Smith, E., (1992) Curr. Opin. Rheumatol., 4, p. 204

[3]

McKellop, H.A., Campbell, P., Park, S.H., Schmalzried, T.P., Grigoris, P., Amstutz, H.C., Sarmiento, A., (1995) Clin. Orthop. Rel. Res., 311, p. 3

[4]

Margevicius, K.J., Bauer, T.W., McMahon, J.T., Brown, S.A., Merritt, K., (1994) J. Bone Joint Surg., 76 A, p. 1664

[5]

Schmalzried, T.P., Jasty, M., Harris, W.H., (1992) J. Bone Joint Surg., 74 A, p. 849

[6]

Shanbhag, A.S., Jacobs, J.J., Glant, T.T., Gilbert, J.L., Black, J., Galante, J.O., (1994) J. Bone Joint Surg., 76 B, p. 60

[7]

Livermore, J., Ilstrup, D., Morrey, B., (1990) J. Bone Joint Surg., 72 A, p. 518

[8]

Isaac, G.H., Atkinson, J.R., Dowson, D., Kennedy, P.D., Smith, M.R., (1987) Eng. Med., 16, p. 167

[9]

Hailey, J.L., Ingham, E., Stone, M., Wroblewski, B.M., Fisher, J., (1996) J. Eng. Med., 210 H, p. 3

[10]

Green, T., Fisher, J., Ingham, E., (1997) Proc. ORS, p. 733

← 1 2 →