Novel patterns of p53 abnormality in breast cancer from Taiwan: Experience from a low-incidence area

被引：23

作者：

Lou M.A. ^{[1
]}

Tseng S.-L. ^{[2
]}

Chang S.-F. ^{[2
]}

Yue C.-T. ^{[3
]}

Chang B.-L. ^{[2
]}

Chou C.-H. ^{[2
]}

Yang S.-L. ^{[2
]}

Teh B.-H. ^{[2
]}

Wu C.-W. ^{[2
]}

Shen C.-Y. ^{[2
,4
]}

机构：

[1] Cardinal Tien Hospital, Taipei

[2] Institute of Biomedical Science, Academia Sinica, Taipei

[3] Mackay Memorial Hospital, Taipei

[4] Institute of Biomedical Sciences, Academia Sinica

来源：

British Journal of Cancer | 1997年 / 75卷 / 5期

关键词：

Breast; Cancer; Human; p53;

D O I：

10.1038/bjc.1997.132

中图分类号：

学科分类号：

摘要：

Among 114 breast cancers in Taiwan, the prevalence of p53 mutation (22.8%) and p53 accumulation (38.3%) was similar to that in high-incidence areas. However, novel patterns of p53 abnormalities, including unique sites or types of mutation (i.e. an excessive proportion of G:C to A:T transition at CpG site), and accumulation of wild-type p53 either within nuclear or cytoplasmic compartments were noted. These may have relevance to breast cancer in Taiwan, a low-incidence area.

引用

页码：746 / 751

页数：5

共 17 条

[1]

Cariello N.F., Cui L., Beroud C., Soussi T., Database and software for the analysis of mutations in the human p53 gene, Cancer Res, 54, pp. 4454-4460, (1994)

[2]

Cho Y., Gorina S., Jeffrey P.D., Pavletich N.P., Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations, Science, 265, pp. 346-355, (1994)

[3]

El-Deiry W.S., Harper J.W., O'Connor P.M., Velculescu V.E., Canman C.E., Jackman J., Pietenpol J.A., Burrel M., Hill D.E., Wang Y., Wiman K.G., Mercer W.W., Kastan M.B., Kohn K.W., Elledge S.J., Kinzler K.W., Vogelstein B., WAF1/CIP1 is induced in p53-mediated G<sub>1</sub> arrest and apoptosis, Cancer Res, 54, pp. 1169-1174, (1994)

[4]

Greenblatt M.S., Bennett W.P., Hollstein M., Harris C.C., Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis, Cancer Res, 54, pp. 4855-4878, (1994)

[5]

Greenblatt M.S., Grollman A.P., Harris C.C., Deletions and insertions in the p53 tumor suppressor gene in human cancers: Confirmation of the DNA polymerase slippage/ misalignment model, Cancer Res, 56, pp. 2130-2136, (1996)

[6]

Hall P.A., Lane D.P., p53 in tumor pathology: Can we trust immunohistochemistry: revisited, J Pathol, 172, pp. 1-4, (1994)

[7]

Liu R.H., Hotchkiss J.H., Potential genotoxicity of chronically elevated nitric oxide: A review, Mutation Res, 339, pp. 73-89, (1995)

[8]

Moll U.M., Riou G., Levine A.J., Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion, Proc Natl Acad Sci USA, 89, pp. 7262-7266, (1992)

[9]

Momand J., Zambetti G.P., Olson D.C., George D., Levine A.J., The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation, Cell, 69, pp. 1237-1245, (1992)

[10]

Orita M., Iwahana H., Kanazawa H., Hayashi K., Sekiya T., Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms, Proc Natl Acad Sci USA, 86, pp. 2766-2770, (1989)

← 1 2 →