Central nervous system toxicity from cancer treatment

被引：4

作者：

Armstrong T. ^{[1
]}

Gilbert M.R. ^{[1
]}

机构：

[1] Department of Neuro-Oncology, M.D. Anderson Cancer Center, Houston, TX 77030

来源：

Current Oncology Reports | 2004年 / 6卷 / 1期

关键词：

Dementia; Status Epilepticus; Methylphenidate; Primary Central Nervous System Lymphoma; Cerebellar Dysfunction;

D O I：

10.1007/s11912-996-0004-x

中图分类号：

学科分类号：

摘要：

Neurologic complications of cancer therapy are an increasingly important concern in patient management. Improvements in systemic therapies and increasing use of local treatments to target such specific tumor sites as brain or leptomeningeal metastases have resulted in increased incidence of treatment toxicity in the central nervous system (CNS). Recognition of specific treatment-related toxicities, and more importantly, differentiation of treatment toxicity from reversible causes of neurologic dysfunction, are critical. This article reviews the evaluation and treatment of major CNS toxicities related to cancer treatment and conditions that present with similar signs and symptoms. The three most common of these, alterations in cognition and consciousness, seizures, and cerebellar dysfunction, are discussed. Prompt recognition of these problems and their causes will have an impact on patient care in all areas of oncology. Copyright © 2004 by Current Science Inc.

引用

页码：11 / 19

页数：8

共 66 条

[1]

Cohen M.Z., Armstrong T.S., Cognitive dysfunction, Cancer Symptom Management, pp. 635-647, (2003)

[2]

Tuma R., DeAngelis L.M., Altered mental status in patients with cancer, Arch. Neurol., 57, pp. 1727-1731, (2000)

[3]

Breitbart W., Strout D., Delirium in the terminally ill, Clin. Geriatr. Med., 16, pp. 357-372, (2000)

[4]

Casarett D.J., Inouye S.K., Diagnosis and management of delirium near the end of life, Ann. Intern. Med., 135, pp. 32-40, (2001)

[5]

Lawlor P.G., Gagnon B., Mancini I.L., Et al., Occurrence, causes, and outcome of delirium in patients with advanced cancer, Arch. Intern. Med., 160, pp. 786-794, (2000)

[6]

Siegal T., Toxicity of treatment for neoplastic meningitis, Curr. Oncol. Rep., 5, pp. 41-49, (2003)

[7]

Bird T., Memory loss and dementia, Harrison's On-Line, (2001)

[8]

Wieneke M.H., Dienst E.R., Neuropsychological assessment of cognitive functioning following chemotherapy for breast cancer, Psycho-Oncology, 4, pp. 61-66, (1995)

[9]

Cimprich B., Ronis D.L., Attention and symptom distress in women with and without breast cancer, Nurs. Res., 50, pp. 86-94, (2001)

[10]

Cull A., Stewart M., Altman D.G., Assessment of and intervention for psychosocial problems in routine oncology practice, Br. J. Cancer, 72, pp. 229-235, (1995)

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