Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng

被引：2

作者：

Ban Y.-H. ^{[1
]}

Cha Y. ^{[1
]}

Choi J. ^{[1
]}

An E.S. ^{[1
]}

Lee J.Y. ^{[1
]}

Han N.R. ^{[1
]}

Seo D.W. ^{[1
]}

Jung G. ^{[2
]}

Jeong D.-H. ^{[3
]}

Rhee M.H. ^{[3
]}

Choi E.-K. ^{[1
]}

Kim Y.-B. ^{[1
]}

机构：

[1] College of Veterinary Medicine, Chungbuk National University, 1 Chungdaero (Gaesin-dong), Cheongju, Chungbuk

[2] R&D Center, Dongkook Pharm Co., Ltd., Jincheon

[3] College of Veterinary Medicine, Kyungpook National University, Daegu

来源：

Laboratory Animal Research | 2017年 / 33卷 / 2期

关键词：

adventitious root; blood flow; ginsenoside; Mountain ginseng; platelet aggregation;

D O I：

10.5625/lar.2017.33.2.105

中图分类号：

学科分类号：

摘要：

Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% FeCl3-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe. Both PARMG and EARMG delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at high doses. In mechanism studies, a high concentration of EARMG inhibited platelet aggregation induced by collagen in vitro. In addition, EARMG improved the blood lipid profiles, decreasing triglyceride and cholesterol levels. Although additional action mechanisms remain to be clarified, it is suggested that ARMG containing high amount of ginsenosides such as Rg3 improves blood flow not only by inhibiting oxidative thrombosis, but also by modifying blood lipid profiles. © 2017, BioMed Central Ltd.

引用

页码：105 / 113

页数：8

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