The potential of peptide immunotherapy in allergy and asthma.

被引：8

作者：

Ali F.R. ^{[1
]}

Kay A.B. ^{[1
]}

Larché M. ^{[1
]}

机构：

[1] Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, Dovehouse Street, London

来源：

Current Allergy and Asthma Reports | 2002年 / 2卷 / 2期

基金：

英国医学研究理事会;

关键词：

Major Histocompatibility Complex; Allergy Clin Immunol; Cell Anergy; House Dust Mite Allergen; Late Asthmatic Reaction;

D O I：

10.1007/s11882-002-0010-5

中图分类号：

学科分类号：

摘要：

Allergic conditions contribute significantly to the burden of chronic disease in the industrialized world. Current treatments offer varying degrees of palliation. The sole proven disease-modifying strategy, specific or whole-allergen immunotherapy, is limited because of the associated risk of systemic adverse effects, such as anaphylaxis. Short, linear allergen-derived peptides, corresponding to T cell epitopes, offer the possibility of a safer approach as they are capable of inducing allergen-specific hyporesponsiveness without cross-linking mast cell-bound IgE. This review evaluates the scientific basis of peptide immunotherapy and clinical experience in allergy up to the present time.

引用

页码：151 / 158

页数：7

共 136 条

[1]

Varney VA(1991)Usefulness of immunotherapy in patients with severe summer hayfever uncontrolled by antiallergic drugs Br Med J 302 265-269

[2]

Gaga M(1997)Clinical efficacy of specific immunotherapy to cat dander: a double-blind placebo-controlled trial Clin Exp Allergy 27 860-867

[3]

Frew AJ(1999)Long-term clinical efficacy of grass-pollen immunotherapy N Engl J Med 341 468-475

[4]

Varney VA(1998)Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper J Allergy Clin Immunol 102 558-562

[5]

Edwards J(1998)Allergen immunotherapy: therapeutic vaccines for allergic diseases Allergy 53 1-42

[6]

Tabbah K(1991)Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma J Clin Invest 87 1541-1546

[7]

Durham SR(1992)Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma N Engl J Med 326 298-304

[8]

Walker SM(1995)Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects Am J Respir Cell Mol Biol 12 477-487

[9]

Varga E-M(1993)Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics Am J Respir Cell Mol Biol 8 35-42

[10]

Bousquet J(1993)Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma J Allergy Clin Immunol 92 313-324

← 1 2 3 4 5 6 7 8 9 10 →