Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions

被引：145

作者：

Adams J.D. ^{[1
]}

Wang R. ^{[2
]}

Yang J. ^{[3
]}

Lien E.J. ^{[2
]}

机构：

[1] Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90089-9121

[2] Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089-9121

[3] Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Southern California, Los Angeles

来源：

Chinese Medicine | / 1卷 / 1期

关键词：

Stroke Patient; Naloxone; Total Effective Rate; Salvianolic Acid; Carthamus Tinctorius;

D O I：

10.1186/1749-8546-1-3

中图分类号：

学科分类号：

摘要：

Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries. The crude drug (dried root) and its preparations are currently used in China to treat patients suffering from heart attack, angina pectoris, stroke and some other conditions. The use of S. miltiorrhiza has been increasing in the management of stroke. Pharmacological examinations showed that the plant and its active ingredients, tanshinones and salvianolic acids, have anticoagulant, vasodilatory, increased blood flow, anti-inflammatory, free radical scavenging, mitochondrial protective and other activities. This review discusses the pharmacology, medicinal chemistry and clinical studies published, especially in China, for danshen and tanshinone preparations. Clinical examinations are evaluated in terms of S. miltiorrhiza preparation, dose, double blinding, control, clinical assessments of outcomes and other parameters. Meta-analyses of S. miltiorrhiza are also discussed. © 2006 Adams et al; licensee BioMed Central Ltd.

引用

共 86 条

[1] Wu B., Liu M., Zhang S., Danshen for acute ischaemic stroke (review), Cochrane Library, 4, pp. 1-12, (2005)
[2] Ji X.Y., Tan B.K.H., Zhu Y.Z., Salvia miltiorrhiza and ischemic diseases, Acta Pharmacol Sin, 21, pp. 1089-1094, (2000)
[3] Adams J.D., Wall M., Garcia C., Salvia columbariae contains tanshinones, Evidence Based Comp Alt Med, 2, pp. 107-110, (2005)
[4] Garcia C., Adams J.D., Healing with medicinal plants of the west-cultural and scientific basis for their use, (2005)
[5] Zhang E., Clinic of traditional Chinese medicine (I), (1988)
[6] Kang D.G., Oh H., Chung H.T., Lee H.S., Inhibition of angiotensin converting enzyme by lithospermic acid B isolated from radix Salviae miltiorrhiza Bunge, Phytother Res, 17, pp. 917-920, (2003)
[7] Gao X.P., Xu D.Y., Deng Y.L., Zhang Y., Screening of angiotensin converting enzyme inhibitors from Salvia miltiorrhiza (Chinese), China J Chin Materia Medica, 29, pp. 359-362, (2004)
[8] Lei X.L., Chiou G.C.Y., Studies on cardiovascular actions of Salvia miltiorrhiza, Am J Chin Med, 14, pp. 26-32, (1986)
[9] Makino T., Wakushima H., Okamoto T., Okukubo Y., Saito K., Kano Y., Effects of kangen-karyu on coagulation system and platelet aggregation in mice, Biol Pharm Bull, 25, pp. 523-525, (2002)
[10] Wang J.Z., Chen M.E., Xu Y.Q., Effect of Salvia miltiorrhiza on angiotensin II and atrial natriuretic polypeptide in rabbits (Chinese), Chin J Mod Devel Trad Med, 11, pp. 420-421, (1991)

← 1 2 3 4 5 6 7 8 9 →