Genetics of migraine and pharmacogenomics: Some considerations

被引：49

作者：

Piane M. ^{[1
]}

Lulli P. ^{[1
]}

Farinelli I. ^{[2
]}

Simeoni S. ^{[3
]}

de Filippis S. ^{[2
]}

Patacchioli F.R. ^{[3
]}

Martelletti P. ^{[2
]}

机构：

[1] Department of Diagnostic Sciences, Medical Genetics Section, University of Rome La Sapienza

[2] Department of Medical Sciences, University of Rome La Sapienza, Internal Medicine, Regional Referral Headache Centre, Rome

[3] Department of Human Physiology and Pharmacology, 2nd School of Medicine, Sapienza University of Rome, Rome

来源：

The Journal of Headache and Pain | 2007年 / 8卷 / 6期

关键词：

Migraine; Non-responder patients; Pharmacogenetics; Pharmacogenomics;

D O I：

10.1007/s10194-007-0427-2

中图分类号：

学科分类号：

摘要：

Migraine is a complex disorder caused by a combination of genetic and environmental factors. Although family and twin studies show that there is a genetic component in migraine, no genes predisposing to common forms of the disorder, migraine with and without aura, have been identified. Patients with migraine respond differently to a given drug administered. The efficacy of therapy and the occurrence of adverse drug response are a consequence of individual variability. Genetic profiling of predisposition to migraine should facilitate the development of more effective diagnostic and therapeutic applications. The development of International Hap Map project could provide a powerful tool for identification of the candidate genes in this complex disease and pharmacogenomics research could be the promise for individualized treatments and prevention of adverse drug response. © Springer-Verlag Italia 2007.

引用

页码：334 / 339

页数：5

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