The good smooth muscle cells in atherosclerosis

被引：104

作者：

Schwartz S.M. ^{[1
]}

Virmani R. ^{[2
]}

Rosenfeld M.E. ^{[1
]}

机构：

[1] Departments of Pathology and Pathobiology, University of Washington, Seattle, WA, 98195-7335

[2] Armed Forces Institute of Pathology, Washington, DC, 20306-6000, 14th and Alaska Ave. NW

来源：

Current Atherosclerosis Reports | 2000年 / 2卷 / 5期

关键词：

Smooth Muscle Cell; Atherosclerotic Lesion; Plaque Rupture; Necrotic Core; Arterioscler Thromb Vasc Biol;

D O I：

10.1007/s11883-000-0081-5

中图分类号：

学科分类号：

摘要：

The formation of a fibrous cap made up of intimal smooth muscle cells and connective tissue is part of an attempt by the vessel wall to encapsulate the toxic products accumulating in the necrotic core of atherosclerotic lesions, and should be viewed as a beneficial healing response. In this review, we discuss the development of the intima and the potential origins of the intimal smooth muscle cell with a focus on the unique properties of these cells. We further discuss the role of intimal smooth muscle cells in plaque rupture and in wound healing, and the relationship of wound healing to the loss of lumen that occurs with development of advanced atherosclerotic lesions.

引用

页码：422 / 429

页数：7

共 78 条

[1]

Ross R, Atherosclerosis: an inflammatory disease, N Engl J Med, 340, pp. 115-126, (1999)

[2]

Wissler RW, Update on the pathogenesis of atherosclerosis, Am J Med, 91, pp. 3S-9S, (1991)

[3]

Schwartz SM, deBlois D, O'Brien ER, The intima. Soil for atherosclerosis and restenosis, Circ Res, 77, pp. 445-465, (1995)

[4]

Parker RE, Granger DN, Cook BH, A histochemical analysis of vascular and nonvascular smooth muscles in the canine lung, Microvasc Res, 18, pp. 167-174, (1979)

[5]

Geer JC, Haust MD, Smooth muscle cells in atherosclerosis, Monogr Atheroscler, 2, pp. 1-140, (1972)

[6]

Haust MD, Myogenic foam cells in explants of fatty dots and streaks from rabbit aorta: morphological studies, Atherosclerosis, 26, pp. 441-464, (1977)

[7]

Faggiotto A, Ross R, Studies of hypercholesterolemia in the nonhuman primate: fatty streak conversion to fibrous plaque, Arteriosclerosis, 4, pp. 341-356, (1984)

[8]

Gerrity RG, The role of the monocyte in atherogenesis: migration of foam cells from atherosclerotic lesions, Am J Pathol, 103, pp. 191-200, (1981)

[9]

Seo HS, Lombardi DM, Polinsky P, Peripheral vascular stenosis in apolipoprotein E-deficient mice: potential roles of lipid deposition, medial atrophy, and adventitial inflammation, Arterioscler Thromb Vasc Biol, 17, pp. 3593-3601, (1997)

[10]

Stary HC, Blankenhorn DH, Chandler AB, A definition of the intima of human arteries and of its atherosclerosis-prone regions, Circulation, 85, pp. 391-405, (1992)

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