Evaluation of white matter damage in patients with Alzheimer's disease and in patients with mild cognitive impairment by using diffusion tensor imaging

被引：72

作者：

Ukmar M. ^{[1
]}

Makuc E. ^{[1
]}

Onor M.L. ^{[2
]}

Garbin G. ^{[3
]}

Trevisiol M. ^{[2
]}

Cova M.A. ^{[1
]}

机构：

[1] Unità Clinica Operativa di Radiologia, Università degli Studi di Trieste, Ospedale di Cattinara, 34149 Trieste

[2] Unità Clinica Operativa di Psichiatria, Università degli Studi di Trieste, 34100 Trieste

[3] BRAIN Center for Neuroscience, Università degli Studi di Trieste, 34100 Trieste

来源：

La radiologia medica | 2008年 / 113卷 / 6期

关键词：

Alzheimer's disease; Diffusion tensor imaging; Magnetic resonance;

D O I：

10.1007/s11547-008-0286-1

中图分类号：

学科分类号：

摘要：

Purpose. The objective of this study was to evaluate white matter tissue damage in patients with Alzheimer's disease (AD) and in patients with mild cognitive impairment (MCI) using diffusion tensor imaging (DTI). Materials and methods. Forty-seven subjects were evaluated: 14 patients with AD, 15 with MCI and 18 healthy volunteers. All subjects were studied using conventional magnetic resonance imaging (MRI) and DTI (32 directions) with a 1.5 T magnet. Fractional anisotropy (FA) was measured in the following regions: frontal, occipital, parietal and temporal white matter and in the genu and splenium of the corpus callosum. The results were compared between the different groups and correlated with the Mini-Mental State Evaluation (MMSE) scores. Results. A statistically significant difference was obtained between controls and MCI patients (p<0.007) and between controls and AD patients (p<0.05) with regard to FA of the white matter in the splenium. A statistically significant difference was obtained between controls and AD patients with regard to FA in the genu (p<0.016). Moreover, there was a statistically significant difference between controls and AD patients considering the genu (p<0.016) and the frontal white matter on the right side (p<0.024). The MMSE scores correlated with the FA values measured in the genu, the splenium and frontal white matter on the right side. No significant differences were identified between patients with AD and those with MCI. Conclusions. DTI could be of value in the early detection of white-matter damage in patients with MCI and AD. The DTI values correlate with the neuropsychological tests. © 2008 Springer-Verlag.

引用

页码：915 / 922

页数：7

共 24 条

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