Aquaporins: Relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus

被引：61

作者：

Owler B.K. ^{[1
,2
,3
]}

Pitham T. ^{[1
]}

Wang D. ^{[1
]}

机构：

[1] Kids Neurosurgical Research Unit, Institute of Neuroscience and Muscle Research, Kids Research Institute, Children's Hospital at Westmead, Westmead NSW 2145, Hawkesbury Rd

[2] TY Nelson Department of Neurology and Neurosurgery, Children's Hospital at Westmead, Westmead NSW 2145, Hawkesbury Rd

[3] Discipline of Child Health and Paediatrics, Children's Hospital at Westmead Clinical School, University of Sydney, Westmead NSW 2145, Hawkesbury Rd

来源：

Cerebrospinal Fluid Research | / 7卷 / 1期

关键词：

Hydrocephalus; Choroid Plexus; AQP4 Expression; Aqueduct Stenosis; Osmotic Permeability;

D O I：

10.1186/1743-8454-7-15

中图分类号：

学科分类号：

摘要：

The discovery of a family of membrane water channel proteins called aquaporins, and the finding that aquaporin 1 was located in the choroid plexus, has prompted interest in the role of aquaporins in cerebrospinal fluid (CSF) production and consequently hydrocephalus. While the role of aquaporin 1 in choroidal CSF production has been demonstrated, the relevance of aquaporin 1 to the pathophysiology of hydrocephalus remains debated. This has been further hampered by the lack of a non-toxic specific pharmacological blocking agent for aquaporin 1. In recent times aquaporin 4, the most abundant aquaporin within the brain itself, which has also been shown to have a role in brain water physiology and relevance to brain oedema in trauma and tumours, has become an alternative focus of attention for hydrocephalus research. This review summarises current knowledge and concepts in relation to aquaporins, specifically aquaporin 1 and 4, and hydrocephalus. It also examines the relevance of aquaporins as potential therapeutic targets in hydrocephalus and other CSF circulation disorders. © 2010 Owler et al; licensee BioMed Central Ltd.

引用

共 97 条

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