Immunization for prevention of infective endocarditis

被引：5

作者：

Baddour L.M. ^{[1
]}

机构：

[1] Department of Medicine, Section of Infectious Diseases, University of Tennessee Medical Center at Knoxville, 1924 Alcoa Highway, Box 114, Knoxville

来源：

Current Infectious Disease Reports | 1999年 / 1卷 / 2期

关键词：

Capsular Polysaccharide; Endocarditis; Infective Endocarditis; Mitral Valve Prolapse; Passive Immunization;

D O I：

10.1007/s11908-996-0018-4

中图分类号：

学科分类号：

摘要：

Immunization has been used for many years to prevent certain infectious diseases. Often it is targeted to populations at increased risk of a particular infection. Patients at increased risk of infective endocarditis can be identified and would be eligible candidates for immunization if vaccines were available to prevent common bacterial causes of infective endocarditis. The idea of using preventive therapy among patients at increased risk of infective endocarditis is not novel, and recommendations for use of antibiotics prior to performing certain invasive procedures have been in place for years. Findings from immunization experiments using animal models of experimental endocarditis support the notion that vaccine development is appropriate for study in humans, and these findings are reviewed in this paper. © 1999, Current Science Inc.

引用

页码：126 / 128

页数：2

共 14 条

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[7] Balaban, N., Goldkorn, T., Nhan, R.T., Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus (1998) Science, 280, pp. 438-440. , PID: 9545222, COI: 1:CAS:528:DyaK1cXivVeksbs%3D, This investigation provides data that indicate that preexisting immunity nonimmunized mice can impact disease severity
[8] Viscount, H.B., Munro, C.L., Burnette-Curley, D., Immunization with FimA protects against Streptococcus parasanguis endocarditis in rats (1997) Infect Immun, 65, pp. 994-1002. , PID: 9038308, COI: 1:CAS:528:DyaK2sXhtlOjsrw%3D, The work described this study supports the notion that active immunization can protect animals against viridans group streptococcal experimental endocarditis
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