NO and the vasculature: Where does it come from and what does it do?

被引：14

作者：

Andrews K.L. ^{[1
]}

Triggle C.R. ^{[1
]}

Ellis A. ^{[1
]}

机构：

[1] Dept. of Pharmacol. and Therapeutics, Faculty of Medicine, University of Calgary, Calgary, Alta. T2N 4N1

来源：

Heart Failure Reviews | 2002年 / 7卷 / 4期

基金：

加拿大健康研究院;

关键词：

Nitric oxide; NO chemistry; Photorelaxation; Vasculature;

D O I：

10.1023/A:1020702215520

中图分类号：

学科分类号：

摘要：

Nitric oxide (NO) is involved in a large number of cellular processes and dysfunctions in NO production have been implicated in many different disease states. In the vasculature NO is released by endothelial cells where it modulates the underlying smooth muscle to regulate vascular tone. Due to the unique chemistry of NO, such as it reactive and free radical nature, it can interact with many different cerellular constituents such as thiols and transition metal ions, which determine its cellular actions. In this review we also discuss many of the useful pharmacological tools that have been developed and used extensively to establish the involvement of NO in endothelium-derived relaxations. In addition, the recent literature identifying a potential source of NO in endothelial cells, which is not directly derived from endothelial nitric oxide synthase is examined. Finally, the photorelaxation phenomena, which mediates the release of NO from a vascular smooth muscle NO store, is discussed.

引用

页码：423 / 445

页数：22

共 164 条

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