Postprandial lipid oxidation and cardiovascular disease risk

被引：50

作者：

Bowen P.E. ^{[1
]}

Borthakur G. ^{[1
]}

机构：

[1] Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL 60612

来源：

Current Atherosclerosis Reports | 2004年 / 6卷 / 6期

关键词：

Reactive Nitrogen Species; Nitrotyrosine; Insulin Lispro; Hydroxy Fatty Acid; Postprandial Lipemia;

D O I：

10.1007/s11883-004-0089-3

中图分类号：

学科分类号：

摘要：

A mild pro-oxidative state accompanies meal ingestion, which results in an increase in biomarkers of inflammation, adhesion, and endothelial dysfunction, all of which are factors in the development of cardiovascular disease. Both fat and carbohydrate can cause the effect, which is additive and exacerbated by diabetes. The presence of lipid, glucose, and cholesterol oxidation products of dietary or endogenous origin may contribute to postprandial oxidative stress. However, the generation of excess superoxide due to abundant energy substrate after the meal may be a predominate factor resulting in oxidative stress and a decrease in nitric oxide, which is important to endothelial function. Remediation of postprandial oxidative stress through direct reduction of superoxide generation and simultaneous consumption of antioxidants with each meal should be a focus of future research. Copyright © 2004 by Current Science Inc.

引用

页码：477 / 484

页数：7

共 56 条

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