Are sleep-related breathing disorders important contributing factors to the production of essential hypertension?

被引:169
作者
Silverberg D.S. [1 ]
Oksenberg A. [1 ]
机构
[1] Department of Nephrology, Tel Aviv Medical Center, Tel Aviv 64239
关键词
Obstructive Sleep Apnea; Continuous Positive Airway Pressure; Essential Hypertension; Obstructive Sleep Apnea Syndrome; Obstructive Sleep Apnoea;
D O I
10.1007/s11906-001-0040-8
中图分类号
学科分类号
摘要
About 50% of all patients with essential hypertension have obstructive sleep apnea (OSA), and another 40% of essential hypertension patients are habitual snorers, but without OSA. There is now convincing evidence that both OSA and habitual snoring are independent risk factors for essential hypertension, and that treatment of OSA will reduce the blood pressure. There is also some evidence that treatment of habitual snoring will also reduce the blood pressure. If this is the case, then we postulate a unifying hypothesis: that these two sleep-related breathing disorders (SRBD) (OSA and habitual snoring) are very common contributing factors to what is called "essential hypertension." The many epidemiologic, clinical, hematologic, biochemical, and physiologic findings seen in essential hypertension could also be due to the associated SRBD. A routine search for SRBD by asking a few simple questions of all patients (especially those with hypertension) and their bed partners could increase the number of patients detected and treated significantly. Successful treatment of SRBD would improve sleep quality and the associated excessive daytime sleepiness, and thus improve the quality of life. In addition, there is a good chance that the hypertension will improve as well. Copyright © 2001 by Current Science Inc.
引用
收藏
页码:209 / 215
页数:6
相关论文
共 56 条
  • [1] Young T., Palta M., Dempsey J., Et al., The occurrence of sleep-disordered breathing among middle-aged adults, N Engl J Med, 328, pp. 1230-1235, (1993)
  • [2] Silverberg D.S., Oksenberg A., Essential and secondary hypertension and sleep disordered breathing: A unifying hypothesis, J Hum Hypertens, 10, pp. 353-363, (1996)
  • [3] Silverberg D.S., Oksenberg A., Essential hypertension and abnormal upper airway resistance during sleep, Sleep, 20, pp. 794-806, (1997)
  • [4] Silverberg D.S., Oksenberg A., Iaina A., Sleep related breathing disorders are common contributing factors to the production of essential hypertension but are neglected, underdiagnosed and undertreated, Am J Hypertens, 10, pp. 1319-1325, (1997)
  • [5] Silverberg D.S., Oksenberg A., Iaina A., Sleep-related breathing disorders as a major cause of essential hypertension: Fact or fiction?, Curr Opin Nephrol Hypertens, 7, pp. 353-357, (1998)
  • [6] Young T., Peppard P., Sleep-disordered breathing and cardiovascular disease: Epidemiologic evidence for a relationship, Sleep, 23, SUPPL. 4, (2000)
  • [7] Fletcher E.C., Cardiovascular consequences of obstructive sleep apnea: Experimental hypoxia and sympathetic activity, Sleep, 23, SUPPL. 4, (2000)
  • [8] Hedner J., Regulation of systemic vasculature in obstructive sleep apnea syndrome, Sleep, 23, SUPPL. 4, (2000)
  • [9] Fletcher E.C., Cardiovascular effects of continuous positive airway pressure in obstructive sleep apnea, Sleep, 23, SUPPL. 4, (2000)
  • [10] Hla K.M., Young T.B., Bidwell T., Et al., Sleep apnea and hypertension: A population-based study, Ann Intern Med, 120, pp. 382-388, (1994)