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Lipoxygenase and cyclooxygenase metabolism: New insights in treatment and chemoprevention of pancreatic cancer

被引：116
作者：
Xian-Zhong Ding
Rene Hennig
Thomas E Adrian
机构：
[1] Department of Surgery, R. H. Lurie Comprehen. Cancer Ctr., Northwestern University, Chicago, IL 60611
来源：
Molecular Cancer | / 2卷 / 1期
关键词：
Cyclooxygenase; Lipoxygenase; Pancreatic cancer;
D O I：
10.1186/1476-4598-2-10
中图分类号：
学科分类号：
摘要：
The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention. © 2003 Ding et al; licensee BioMed Central Ltd.
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页数：12
相关论文
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