CDP840: A Novel Inhibitor of PDE-4

被引：25

作者：

Perry M.J. ^{[1
]}

O'Connell J. ^{[1
]}

Walker C. ^{[1
]}

Crabbe T. ^{[1
]}

Baldock D. ^{[1
]}

Russell A. ^{[1
]}

Lumb S. ^{[1
]}

Huang Z. ^{[2
]}

Howat D. ^{[1
]}

Allen R. ^{[1
]}

Merriman M. ^{[1
]}

Walls J. ^{[1
]}

Daniel T. ^{[1
]}

Hughes B. ^{[1
]}

Laliberte F. ^{[2
]}

Higgs G.A. ^{[1
]}

Owens R.J. ^{[1
]}

机构：

[1] Celltech Therapeutics Limited, Slough SL1 4EN

[2] Merck Frosst Canada Inc., Kirkland, Que.

来源：

Cell Biochemistry and Biophysics | 1998年 / 29卷 / 1-2期

关键词：

CDP840; rolipram; [; H]-rolipram; cAMP; asthma; nausea; kinetics; PDE-4;

D O I：

10.1007/BF02737831

中图分类号：

学科分类号：

摘要：

[No abstract available]

引用

页码：113 / 132

页数：19

共 35 条

[1]

Palfreyman M.N., Souness J.E., Phosphodiesterase type IV inhibitors, Prog. Med. Chem., 33, pp. 1-52, (1996)

[2]

Torphy T.J., Livi G., Christensen S., Novel phosphodiesterase inhibitors for the therapy of asthma, Drug News Perspect., 6, pp. 203-214, (1993)

[3]

Torphy T.J., Undem B.J., Phosphodiesterase inhibitors new opportunities for the treatment of asthma, Thorax., 46, pp. 512-523, (1991)

[4]

Saletu B., EEG mapping and psychopharmacology with denbufylline in SDAT and MID, Biol. Psychiatry, 32, pp. 668-681, (1992)

[5]

Brunne T., Engelstatter R., Steinijans V.W., Kunkel G., Bronchodilator effects of inhaled Zardaverine, a phosphodiesterase 3 and 4 inhibitor in patients with asthma, Eur. Respir. J., 5, pp. 982-985, (1992)

[6]

Hebenstrieb G.H., Rolipram in major depressive disorders results of a double blind comparative study with imipramine, Pharmacol. Psychiatr., 22, pp. 156-160, (1989)

[7]

Swinnen J.V., Joseph D.R., Conti M., Molecular cloning of rat homologues of the Urosophilia melanogaster dunce cAMP phosphodiesterase, Proc. Natl. Acad. Sci. USA, 86, pp. 5325-5329, (1989)

[8]

Bolger G., Michaeli T., Martins T., St John T., Steiner B., Rodgers L., Riggs M., Ferguson K., A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs, Mol Cell Biol., 13, pp. 6558-6571, (1993)

[9]

Hughes B., Owens R.J., Perry M.J., Warrellow G., Allen R., PDE 4 inhibitors: The use of molecular cloning in the design and development of novel drugs, Drug Disc. Today, 2, pp. 89-101, (1997)

[10]

Huston E., Pooley L., Julien P., Scotland G., McPhee I., Sullivan M., Bolger G., Houslay M.D., The human cyclic AMP-specific phosphodiesterase PDE 46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the anti-depressant rolipram, J. Biol. Chem., 271, pp. 31334-31344, (1996)

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