Nitric oxide synthases and osteoarthritis

被引：102

作者：

Scher J.U. ^{[1
]}

Pillinger M.H. ^{[1
]}

Abramson S.B. ^{[1
]}

机构：

[1] Division of Rheumatology, New York University School of Medicine, New York University Hospital for Joint Diseases, New York, NY 10003

来源：

Current Rheumatology Reports | 2007年 / 9卷 / 1期

关键词：

Nitric Oxide; Articular Cartilage; Hyaluronic Acid; Peroxynitrite; Articular Chondrocytes;

D O I：

10.1007/s11926-007-0016-z

中图分类号：

学科分类号：

摘要：

The production of nitric oxide (NO) by chondrocytes is increased in human osteoarthritis. The excessive production of NO inhibits matrix synthesis and promotes its degradation. Furthermore, by reacting with oxidants such as superoxide anion, NO promotes cellular injury and renders the chondrocyte susceptible to cytokine-induced apoptosis. Thus, NO produced by activated chondrocytes in diseased cartilage may modulate disease progression in osteoarthritis and should therefore be considered a potential target for therapeutic intervention. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：9 / 15

页数：6

共 33 条

[1]

Pelletier J.P., Martel-Pelletier J., Abramson S.B., Osteoarthritis, an inflammatory disease: Potential implication for the selection of new therapeutic targets, Arthritis Rheum, 44, pp. 1237-1247, (2001)

[2]

Korhonen R., Lahti A., Kankaanranta H., Moilanen E., Nitric oxide production and signaling in inflammation, Review of NO production and signaling in inflammation, 4, pp. 471-479, (2005)

[3]

Henrotin Y., Kurz B., Aigner T., Oxygen and reactive oxygen species in cartilage degradation: Friends or foes?, Osteoarthritis Cartilage, 13, pp. 643-654, (2005)

[4]

Hess D.T., Matsumoto A., Kim S.O., Et al., Protein S-nitrosylation: Purview and parameters, Nat Rev Mol Cell Biol, 6, pp. 150-166, (2005)

[5]

Kleinert H., Schwarz P.M., Forstermann U., Regulation of the expression of inducible nitric oxide synthase, Biol Chem, 384, pp. 1343-1364, (2003)

[6]

Kleinert H., Pautz A., Linker K., Schwarz P.M., Regulation of the expression of inducible nitric oxide synthase, Eur J Pharmacol, 500, pp. 255-266, (2004)

[7]

Teixeira C.C., Ischiropoulos H., Leboy P.S., Et al., Nitric oxidenitric oxide synthase regulates key maturational events during chondrocyte terminal differentiation, Bone, 37, pp. 37-45, (2005)

[8]

Amin A.R., Di Cesare P.E., Vyas P., Et al., The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: Evidence for up-regulated neuronal nitric oxide synthase, J Exp Med, 182, pp. 2097-2102, (1995)

[9]

Loeser R.F., Carlson C.S., Del Carlo M., Cole A., Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1, Arthritis Rheum, 46, pp. 2349-2357, (2002)

[10]

van der Harst M., Bull S., Brama P.A., Et al., Nitrite and nitrotyrosine concentrations in articular cartilage, subchondral bone, and trabecular bone of normal juvenile, normal adult, and osteoarthritic adult equine metacarpophalangeal joints, J Rheumatol, 33, pp. 1662-1667, (2006)

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