Community-acquired MRSA and pig-farming

被引：280

作者：

Huijsdens X.W. ^{[1
]}

van Dijke B.J. ^{[2
]}

Spalburg E. ^{[1
]}

van Santen-Verheuvel M.G. ^{[1
]}

Heck M.E.O.C. ^{[1
]}

Pluister G.N. ^{[1
]}

Voss A. ^{[3
,4
]}

Wannet W.J.B. ^{[1
]}

de Neeling A.J. ^{[1
]}

机构：

[1] National Institute for Public Health and the Environment (RIVM), Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, 3720 BA Bilthoven

[2] St. Jansgasthuis Department of Medical Microbiology, 6000 AA Weert

[3] Radboud University Medical Centre, Department of Medical Microbiology, 6500 HB Nijmegen

[4] Canisius-Wilhelmina Hospital, Department of Medical Microbiology, 6500 GS Nijmegen

来源：

Annals of Clinical Microbiology and Antimicrobials | / 5卷 / 1期

关键词：

Mastitis; Teicoplanin; SCCmec Type; Enrichment Broth; ST398 Strain;

D O I：

10.1186/1476-0711-5-26

中图分类号：

学科分类号：

摘要：

Background: Sporadic cases of CA-MRSA in persons without risk-factors for MRSA carriage are increasing. Case presentation: We report a MRSA cluster among family members of a pig-farmer, his co-workers and his pigs. Initially a young mother was seen with mastitis due to MRSA. Six months later her baby daughter was admitted to the hospital with pneumococcal otitis. After staying five days in hospital, the baby was found to be MRSA positive. At that point it was decided to look for a possible source, such as other family members and house-hold animals, including pigs on the farm, since those were reported as a possible source of MRSA earlier. Swabs were taken from the throat and nares of family members and co-workers. A veterinarian obtained swabs from the nares, throat and perineum of 10 pigs. Swabs were cultured following a national protocol to detect MRSA that included the use of an enrichment broth. Animal and human strains were characterized by PFGE, spa-typing, MLST analysis, SSCmec, AGR typing, and the detection for PVL, LukM, and TSST toxin genes. Three family members, three co-workers, and 8 of the 10 pigs were MRSA positive. With the exception of the initial case (the mother) all persons were solely colonized, with no signs of clinical infections. After digestion with Smal, none of the strains showed any bands using PFGE. All isolates belonged to spa type t108 and ST398. Conclusion: 1. This report clearly shows clonal spread and transmission between humans and pigs in the Netherlands. 2. MILST sequence type 398 might be of international importance as pig-MRSA, since this type was shown earlier to be present in epidemiologically unrelated French pigs and pig-farmers. 3. Research is needed to evaluate whether this is a local problem or a new source of MRSA, that puts the until now successful Search and Destroy policy of the Netherlands at risk. © 2006 Huijsdens et al; licensee BioMed Central Ltd.

引用

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