COX-2, NO, and cartilage damage and repair.

被引：109

作者：

Amin A.R. ^{[1
]}

Dave M. ^{[1
]}

Attur M. ^{[1
]}

Abramson S.B. ^{[1
]}

机构：

[1] Medicine, Hospital for Joint Diseases, Room 1410, 301 East 17th Street, New York, 10003, NY

来源：

Current Rheumatology Reports | 2000年 / 2卷 / 6期

关键词：

Nitric Oxide; Cartilage Explants; Osteoarthritis Cartilage; Human Articular Chondrocytes; Chondrocyte Apoptosis;

D O I：

10.1007/s11926-000-0019-5

中图分类号：

学科分类号：

摘要：

The production of nitric oxide (NO) and prostaglandin E2 (PGE(2)) is increased in human osteoarthritis-affected cartilage. These and other inflammatory mediators are spontaneously released by OA cartilage explants ex vivo. The excessive production of nitric oxide inhibits matrix synthesis, and promotes its degradation. Furthermore, by reacting with oxidants such as superoxide anion, nitric oxide promotes cellular injury, and renders the chondrocyte susceptible to cytokine-induced apoptosis. PGE(2) exerts both anabolic and catabolic effects on chondrocytes, depending on the microenvironment and physiological condition. Thus, NO and PGE(2), produced by activated chondrocytes in diseased cartilage, may modulate disease rogression in osteoarthritis, and should therefore be considered potential targets for therapeutic intervention

引用

页码：447 / 453

页数：6

共 127 条

[1] Sakurai H(1995)Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides J Clin Invest 96 2357-2363
[2] Kohsaka H(1998)Serum levels of a prostaglandin and a leukotriene after thermal mud pack therapy J Investig Med 46 140-145
[3] Liu MF(1989)Leukotriene B4, leukotriene C4 and prostaglandin E2 in the serum, synovial fluid and synovium in patients with rheumatoid arthritis Nippon Ika Daigaku Zasshi 56 559-564
[4] Bellometti S(2000)Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium J Korean Med Sci 15 88-92
[5] Galzigna L(1998)Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis Arthritis Rheum 41 2165-2174
[6] Sawazaki Y(1998)The role of nitric oxide in articular cartilage breakdown in osteoarthrtis Curr Opin Rheumatol 10 263-268
[7] Lee YH(1995)The expression and regulation of nitric oxide synthase in human osteoarthritisaffected chondrocytes: Evidence for up-regulated neuronal nitric oxide synthase J Exp Med 182 2097-2102
[8] Choi SJ(1997)Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage: Influence of nitric oxide J Clin Invest 99 1231-1237
[9] Kim A(1997)Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex J Clin Invest 100 1789-1796
[10] Melchiorri C(1992)Role of nitric oxide in modulating permeability of hamster cheek pouch in response to adenosine 5′-diphosphate and bradykinin Inflammation 16 295-305

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