Image analysis measurements of the microvascularisation in endometrium, superficial and deep endometriotic tissues

被引：12

作者：

Jondet M. ^{[1
]}

Vacher-Lavenu M.C. ^{[2
]}

Chapron C. ^{[3
]}

Vacher-Lavenu M.C. ^{[2
]}

Chapron C. ^{[3
]}

机构：

[1] Cabinet de Pathologie, 75014 Paris

[2] Service Central d'Anatomie et de Cytologie Pathologiques, Hôpital Cochin, Paris

[3] Assistance Publique-Hôpitaux de Paris, Université René Descartes

[4] Service de Gynécologie Obstétrique II et Médecine de la Reproduction, Clinique Universitaire Baudelocque, Hôpital Cochin, 75014 Paris, 123, bd Port-Royal

来源：

Angiogenesis | 2006年 / 9卷 / 4期

关键词：

Endometriosis; Endometrium; Image analysis; Microvascularisation; Progestin;

D O I：

10.1007/s10456-006-9044-y

中图分类号：

学科分类号：

摘要：

The aim of this study was to evaluate precisely the microvascularisation of endometrium, superficial and deep endometriotic lesions, in progestin-treated and non-treated patients suffering from endometriosis. Methods: A population of 66 women was constituted. Immunohistochemistry was carried out with a specific marker of the endothelial cells (CD31). The number of vessels and the vessel area were assessed by a computer image analysis system. Results: The number of vessels per mm 2 were 211, 216, 225 and the vessel area was 270, 141 and 194 μm2, respectively in endometria, superficial and deep endometriotic lesions of untreated women. In endometria, superficial and deep endometriotic lesions of progestin-treated women the number of vessels were respectively 129, 149, and 181 per mm2 and the vessel area was 369, 474 and 254 μm2. Conclusion: Statistically significant data indicate that endometriotic lesions are heterogeneous and suggest that progestin treatment induces a reduction in number and a concomitant dilation of microvessels with more microvascular changes in endometrium and superficial endometriotic lesions than in deep endometriotic lesions. © Springer Science+Business Media B.V. 2006.

引用

页码：177 / 182

页数：5

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