Study on the relationship between calcium-induced calcium release from mitochondria and PTP opening

被引：10

作者：

Xingxu Huang

Dayong Zhai

Youguo Huang

机构：

[1] Institute of Biophysics,National Laboratory of Biomacromolecules

[2] Academia Sinica,National Laboratory of Biomacromolecules

[3] Institute of Biophysics,undefined

[4] Academia Sinica,undefined

来源：

Molecular and Cellular Biochemistry | 2000年 / 213卷

关键词：

mCICR; low-conductance conformation; high-conductance conformation; permeability transition pore; mitochondria;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The permeability transition pore (PTP) is central for mitochondria function. PTP either open in low-conductance state to carry out mCICR (Ca2+-induced Ca2+ release from mitochondria) and play roles in cell phsyiological activities or open in high-conductance conformation to release harmful substances and play important roles in cell pathological responses and apoptosis. The results of study on the relationship between mCICR and PTP opening show Ca2+ concentrations but not the Ca2+ delivery mode determined the occurrence of mCICR or PTP opening. Ca2+-induced PTP opening began with and depended on mCICR. mCICR was a prerequisite for H2O2 and As2O3-induced PTP opening. The results indicated that the PTP opening was determined by Ca2+ stimulation intensity but not mode. PTP could switch from low- to high-conductance conformation and the PTP open by high-conductance began with low-conductance state. mCICR is necessary for Ca2+-dependent PTP opening. Our data suggested also that it would be possible to control cellular responses first by modulating mCICR, then by regulating PTP opening.

引用

页码：29 / 35

页数：6

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