Emerging Molecular Targets for Intravascular Imaging of High-Risk Plaques

被引：6

作者：

Kim J.W. ^{[1
,2
]}

Jaffer F.A. ^{[3
]}

机构：

[1] Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA

[2] Cardiovascular Center, Korea University, Guro Hospital, Seoul

[3] Cardiovascular Research Center, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114-2790, Simches Research Building, 3206

来源：

Current Cardiovascular Imaging Reports | 2010年 / 3卷 / 4期

关键词：

Atherosclerosis; Fluorescence; Intravascular; Molecular imaging; Thrombosis;

D O I：

10.1007/s12410-010-9028-6

中图分类号：

学科分类号：

摘要：

Accumulating evidence links catastrophic cardiovascular events to the inflammatory, angiogenic, and apoptotic biological profiles underlying high-risk atherosclerotic plaques. While biological detail is opaque to traditional anatomical imaging readouts, emerging molecular imaging approaches are now yielding significant clinical insights into the biological diagnosis, characterization, and treatment of atherosclerotic vascular disease. Yet, while clinical molecular imaging approaches are available for larger arterial beds such as the carotid arteries or aorta, molecular imaging pathways for human coronary arterial plaques are lacking. Excitingly, the recent advent of intravascular near-infrared fluorescence technology now offers new potential for in vivo molecular imaging of key molecular and cellular targets in coronary-sized vasculature. Here we provide a framework for coronary artery-targeted molecular imaging using intravascular imaging technology, and present key molecular imaging targets relevant to the detection of high-risk, vulnerable coronary plaques. © 2010 Springer Science+Business Media, LLC.

引用

页码：237 / 247

页数：10

共 47 条

[1]

Nissen S.E., The vulnerable plaque "hypothesis": promise, but little progress, JACC Cardiovasc Imaging, 2, pp. 483-485, (2009)

[2]

Choi S.H., Chae A., Chen C.H., Et al., Emerging approaches for imaging vulnerable plaques in patients, Curr Opin Biotechnol, 18, pp. 73-82, (2007)

[3]

Libby P., Inflammation in atherosclerosis, Nature, 420, pp. 868-874, (2002)

[4]

Jaffer F.A., Libby P., Weissleder R., Molecular imaging of cardiovascular disease, Circulation, 116, pp. 1052-1061, (2007)

[5]

Sanz J., Fayad Z.A., Imaging of atherosclerotic cardiovascular disease, Nature, 451, pp. 953-957, (2008)

[6]

Calfon M.A., Vinegoni C., Ntziachristos V., Et al., Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques, J Biomed Optics, 15, (2010)

[7]

Weissleder R., Ntziachristos V., Shedding light onto live molecular targets, Nat Med, 9, pp. 123-128, (2003)

[8]

Ntziachristos V., Ripoll J., Wang L.V., Et al., Looking and listening to light: the evolution of whole-body photonic imaging, Nat Biotechnol, 23, pp. 313-320, (2005)

[9]

Jaffer F.A., Libby P., Weissleder R., Optical and multimodality molecular imaging: insights into atherosclerosis, Arterioscler Thromb Vasc Biol, 29, pp. 1017-1024, (2009)

[10]

Ntziachristos V., Tung C.H., Bremer C., Et al., Fluorescence molecular tomography resolves protease activity in vivo, Nat Med, 8, pp. 757-760, (2002)

← 1 2 3 4 5 →