Progress in unraveling the genetics of coronary artery disease and myocardial infarction

被引：19

作者：

Anderson J.L. ^{[1
]}

Carlquist J.F. ^{[1
]}

Horne B.D. ^{[1
]}

Hopkins P.N. ^{[1
]}

机构：

[1] Department of Cardiology, LDS Hospital, Salt Lake City, UT 84143

来源：

Current Atherosclerosis Reports | 2007年 / 9卷 / 3期

关键词：

Coronary Heart Disease Risk; Cholesteryl Ester Transfer Protein; Haplotype Block; Genetic Risk Score; Premature Coronary Heart Disease;

D O I：

10.1007/s11883-007-0017-4

中图分类号：

学科分类号：

摘要：

Atherosclerosis is a leading cause of morbidity and mortality. Coronary artery disease (CAD) and its clinical manifestation, myocardial infarction (MI), are equally determined by interacting environmental and (largely unknown) multigenic factors. Genome-wide and candidate gene searches for single nucleotide polymorphism (SNP) associations with CAD/ MI (ie, coronary heart disease) often have resulted in nonreproducible or weak associations. Associations with intermediate surrogates have not ensured clinical event predicitons. Linked SNP groups (haplotypes) can be more informative than indivudual SNPs unless the functional gene variant is known with certainty. Recent results of genetic association studies challenge the "common disease-common variant" hypothesis and suggest that multiple, relatively uncommon alleles often determine variation in coronary risk factors (eg, low high-density lipoprotein). Generic risk scores, generated by considering several functional SNPs or haplotypes in multiple genes within a biologic pathway implicated in coronary heart disease, could improve predictive ability. Despite the complexity of coronary heart disease genetics, steady progress can be exptected. © 2007 by Current Medicine Group LLC.

引用

页码：179 / 186

页数：7

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