The gene encoding interleukin-13: A susceptibility locus for asthma and related traits

被引：22

作者：

Wills-Karp M. ^{[1
]}

机构：

[1] Dept. of Environ. Health Sciences, Johns Hopkins University, Baltimore, MD 21205

来源：

Respiratory Research | 2000年 / 1卷 / 1期

关键词：

Asthma; Atopy; Genetics; Interleukin-13; Interleukin-4; receptor;

D O I：

10.1186/rr7

中图分类号：

学科分类号：

摘要：

Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discuss several recent studies that have identified polymorphisms in the gene encoding interleukin-13. The consistent genetic associations of interleukin-13 with asthma and related traits across diverse ethnic populations in these studies provides strong support for the candidacy of this cytokine as a susceptibility locus for asthma and atopy on chromosome 5q31.

引用

页码：19 / 23

页数：4

共 34 条

[1]

Daniels S.E., Bhattacharrya S., James A., Leaves N.I., Young A., Hill M.R., Faux J.A., Ryan G.F., le Souef P.N., Lathrop G.M., Musk A.W., Cookson W.O., A genome-wide search for quantitative trait loci underlying asthma, Nature, 383, pp. 247-250, (1996)

[2]

A genome-wide search for asthma susceptibility loci in ethnically diverse populations, Nat. Genet., 15, pp. 389-392, (1997)

[3]

Ober C., Cox N.J., Abney M., Di Rienzo A., Lander E.S., Changyaleket B., Gidley H., Kurtz B., Lee J., Nance M., Pettersson A., Prescott J., Richardson A., Schlenker E., Summerhill E., Willadsen S., Parry R., Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma, Hum. Mol. Genet., 7, pp. 1393-1398, (1997)

[4]

Wjst M., Fischer G., Immervoll T., Jung M., Saar K., Rueschendorf F., Reis A., Ulbrecht M., Gomolka M., Weiss E.H., Jaeger L., Nickel R., Richter K., Kjellman N.I., Griese M., von Berg A., Gappa M., Riedel F., Boehle M., van Koningsbruggen S., Schoberth P., Szczepanski R., Dorsch W., Silbermann M., Wichmann H.E., Et al., A genome-wide search for linkage to asthma, Genomics, 58, pp. 1-8, (1999)

[5]

Ober C., Tsalenko A., Willadsen S., Newman D., Daniel R., Wu X., Andal J., Hoki D., Schneider D., True K., Schou C., Parry R., Cox N., Genome-wide screen for atopy susceptibility alleles in the Hutterites, Clin. Exp. Allergy, 29, SUPPL. 4, pp. 11-15, (1999)

[6]

Wjst M., Specific IgE - One gene fits all?, Clin. Exp. Allergy, 4, pp. 5-10, (1999)

[7]

Marsh D.G., Neely J.D., Breazeale D.R., Ghosh B., Friedhoff L.R., Ehrlich E., Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations, Science, 264, pp. 1152-1156, (1994)

[8]

Postma D.S., Bleecker E.R., Amelung P.J., Holroyd K.J., Xu J., Panhuysen C.I., Meyers D.A., Levitt R.C., Genetic susceptibility to asthmabronchial hyperresponsiveness coinherited with a major gene for atopy, N. Engl. J. Med., 333, pp. 894-900, (1995)

[9]

Borish L., Mascali J.J., Klinnert M., Leppert M., Rosenwasser L.J., SSC polymorphisms in interleukin genes, Hum. Mol. Genet., 4, (1995)

[10]

Burchard E.G., Silverman E.K., Rosenwasser L.J., Borish L., Yandava C., Pillari A., Weiss S.T., Hasday J., Lilly C.M., Ford J.G., Drazen J.M., Association between a sequence variant in the IL-4 gene promoter and FEV1 in asthma, Am. J. Respir. Crit. Care Med., 160, pp. 919-922, (1999)

← 1 2 3 4 →