Novel vascular targeting/disrupting agents: Combretastatin A4 phosphate and related compounds

被引：39

作者：

Cooney M.M. ^{[1
]}

Ortiz J. ^{[1
]}

Bukowski R.M. ^{[1
]}

Remick S.C. ^{[1
]}

机构：

[1] Developmental Therapeutics Program, Case Comprehensive Cancer Center, Univ. Hospitals of Cleveland Clinic, Cleveland, OH 44106

来源：

Current Oncology Reports | 2005年 / 7卷 / 2期

关键词：

Maximal Tolerate Dose; Tumor Vasculature; Anaplastic Thyroid Cancer; Tumor Perfusion; Tumor Blood Flow;

D O I：

10.1007/s11912-005-0033-x

中图分类号：

学科分类号：

摘要：

Novel anticancer compounds are being developed that attempt to exploit the unique properties of the vascular endothelium, which supplies rapidly dividing neoplasms. The goal of these vascular targeting agents (VTAs) or endothelial disrupting agents is to cause rapid shutdown of tumor blood supply with subsequent tumor death from hypoxia and nutrient deprivation. VTAs are classified into two broad categories: biologic therapies or small molecule compounds. A variety of VTAs are in early clinical development. These agents have demonstrated clinical activity in phase I trials and are being evaluated with cytotoxic chemotherapy and radiotherapy. Copyright © 2005 by Current Science Inc.

引用

页码：90 / 95

页数：5

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