Granulomatous vasculitis

被引：8

作者：

Javier Marquez

Diana Flores

Liliana Candia

Luis R. Espinoza

机构：

[1] Section of Rheumatology, Department of Medicine, Louisiana State University, 1542 Tulane Avenue, New Orleans, 70112, LA

来源：

Current Rheumatology Reports | 2003年 / 5卷 / 2期

关键词：

Giant Cell Arteritis; Montelukast; Systemic Vasculitis; Takayasu Arteritis; Vasculitis;

D O I：

10.1007/s11926-003-0040-6

中图分类号：

学科分类号：

摘要：

Granulomatous vasculitis is a subset of systemic necrotizing vasculitis and has granulomatous inflammation as the main histopathologic feature. Etiopathogenesis remains poorly understood, although recent advances suggest an important role for certain pro-inflammatory cytokines, such as tumor necrosis factor-alpha. They are a heterogeneous group of clinical disorders with protean manifestations. Serologic abnormalities are present, and the presence of granular cytoplasmic staining-antineutrophil cytoplasmic antibodies is most important and is particularly useful for the diagnosis of active Wegener’s granulomatosis. Corticosteroids and cyclophosphamide remain very useful in the treatment of most of these disorders. © 2003, Current Science Inc.

引用

页码：128 / 135

页数：7

共 49 条

[1]

Cuchacovich R., Immunopathogenesis of vasculitis, Curr Rheum Rep, 4, pp. 9-17, (2002)

[2]

Gonzalez-Gay M., Garcia-Porrua C., Systemic vasculitis in adults in northwestern Spain, 1988–1997, Medicine, 78, pp. 292-308, (1999)

[3]

Csernok E., Trabandt A., Muller A., Et al., Cytokines profiles in Wegener’s granulomatosis: predominance of type 1 (Th1) in the granulomatous inflammation, Arthritis Rheum, 42, pp. 742-750, (1999)

[4]

Sneller C., Granuloma formation, implications for the pathogenesis of vasculitis, Cleve Clin J Med, 69, pp. 40-43, (2002)

[5]

Numano F., The story of Takayasu arteritis, Rheumatology, 41, pp. 103-106, (2002)

[6]

Hoffman G.S., Takayasu’s arteritis lessons from the American National Institutes of Health experience, Int J Cardiol, 54, pp. S99-S102, (1996)

[7]

Kimura A., Kimura H., Date Y., Et al., Comprehensive analysis of HLA genes in Takayasu’s arteritis in Japan, Int J Cardiol, 54, pp. S61-S69, (1996)

[8]

Mehra N.K., Rajalingam R., Sagar S., Et al., Direct role of HLA-B5 in influencing susceptibility to Takayasu’s aortoarteritis, Int J Cardiol, 54, pp. S71-S79, (1996)

[9]

Arend W., Michael A.A., Bloch D.A., Et al., The American College of Rheumatology criteria for the classification of Takayasu’s arteritis, Arthritis Rheum, 33, pp. 1129-1134, (1990)

[10]

Chun Y.S., Park S.J., Park I.K., Et al., The clinical and ocular manifestations of Takayasu’s arteritis, Retina, 2, pp. 1132-1140, (2001)

← 1 2 3 4 5 →