Intestinal mesenchymal cells

被引：81

作者：

Pinchuk I.V. ^{[1
]}

Mifflin R.C. ^{[1
]}

Saada J.I. ^{[1
]}

Powell D.W. ^{[1
,2
]}

机构：

[1] Department of Internal Medicine, University of Texas Medical Branch, Galveston

[2] Departments of Internal Medicine and Neuroscience and Cell Biology, Galveston, TX 77555-0764, 4.106 McCullough 0764

来源：

Current Gastroenterology Reports | 2010年 / 12卷 / 5期

基金：

美国国家卫生研究院;

关键词：

Adaptive immunity; Alpha smooth muscle actin; Antigen presentation; Cancer microenvironment; Colorectal cancer; Fibrocyte; Inflammation; Inflammatory bowel disease; Innate immunity; Intestinal immunity; Intestinal inflammation; Intestinal morphogenesis; Lymphatic lacteal; Mesenchymal stem cell; Mucosal immunology; Mucosal tolerance; Muscularis mucosae; Myofibroblast; Pericyte; Programmed cell death ligands; Regulatory T cell; Stem cell niche; Stromal cell;

D O I：

10.1007/s11894-010-0135-y

中图分类号：

学科分类号：

摘要：

The non-white blood cell mesenchymal elements of the intestinal lamina propria are the myofibroblasts, fibroblasts, pericytes, stromal stem cells, muscularis mucosae, and the smooth muscle of the villus core associated with the lymphatic lacteal. We review the functional anatomy of these mesenchymal cells, what is known about their origin in the embryo and their replacement in adults, their putative role in intestinal mucosal morphogenesis, and the intestinal stem cell niche, and we consider new information about myofibroblasts as nonprofessional immune cells. Although our knowledge of the function of mesenchymal cells in intestinal disease is rudimentary, we briefly consider here their roles in cancer and intestinal inflammation. © 2010 Springer Science+Business Media, LLC.

引用

页码：310 / 318

页数：8

共 51 条

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