Common Human 5′ Dopamine Transporter (SLC6A3) Haplotypes Yield Varying Expression Levels In Vivo

被引：40

作者：

Tomas Drgon ^{[1
]}

Zhicheng Lin ^{[2
]}

Gene-Jack Wang ^{[2
]}

Joanna Fowler ^{[2
]}

Johnfn Pablo ^{[2
]}

Deborah C. Mash ^{[3
]}

Nora Volkow ^{[3
]}

George R. Uhl ^{[4
]}

机构：

[1] NIDA-IRP,Molecular Neurobiology Branch

[2] NIH,Department of Neurology

[3] DHSS,Office of the Director

[4] Brookhaven National Laboratories,undefined

[5] University of Miami School of Medicine,undefined

[6] NIDA,undefined

[7] NIH,undefined

[8] DHSS,undefined

来源：

Cellular and Molecular Neurobiology | 2006年 / 26卷 / 4期

关键词：

haplotype; dopamine transporter; cocaine; Parkinson's disease; PET; postmortem brain;

D O I：

10.1007/s10571-006-9014-3

中图分类号：

学科分类号：

摘要：

1. Individuals display significant differences in their levels of expression of the dopamine transporter (DAT; SLC6A3). These differences in DAT are strong candidates to contribute to individual differences in motor, mnemonic and reward functions. To identify “cis”-acting genetic mechanisms for these individual differences, we have sought variants in 5′ aspects of the human DAT gene and identified the haplotypes that these variants define.

引用

页码：873 / 887

页数：14