Prevalence of antibodies against the human granulocytic ehrlichiosis agent in Lyme borreliosis patients from Germany

被引：29

作者：

Hunfeld K.-P. ^{[1
]}

Brade V. ^{[1
]}

机构：

[1] Institute of Medical Microbiology, University Hospital of Frankfurt, Theodor-Stern-Kai 7

来源：

European Journal of Clinical Microbiology and Infectious Diseases | 1999年 / 18卷 / 3期

关键词：

Lyme Disease; Clinical Microbiology; Borrelia Burgdorferi; Tick Bite; Ehrlichiosis;

D O I：

10.1007/s100960050264

中图分类号：

学科分类号：

摘要：

To contribute to the discussion of whether or not human granulocytic ehrlichiosis (HGE) occurs in midwestern Germany, sera from individuals with different risk categories for tick exposure were retrospectively examined by means of an immunofluorescence assay. The seroreprevalence for the HGE agent accounted for 5.5% of the 270 patients tested. Specific antibodies were detected more often in patients with early Lyme infection than in patients with stage III disease or in asymptomatic individuals seropositive for Lyme disease. Investigation of 50 patients with an active or recent syphilis infection revealed no crossreactivity between Treponema pallidum antibodies and the HGE agent. The prevalence of HGE antibodies (13.1%) among 76 Lyme borreliosis patients from this urban area was significantly higher (P < 0.05) than that in the control groups (2.6%). The findings indicate that concomitant or serial infections with Borrelia burgdorferi and the HGE agent or closely related organisms may be a common occurrence in tick-exposed patients from Germany.

引用

页码：221 / 224

页数：3

共 19 条

[1]

Granström, M., Tick-borne zoonoses in Europe (1997) Clinical Microbiology and Infection, 3, pp. 156-169

[2]

Bakken, J.S., Dumler, J.S., Chen, S.M., Eckman, M.R., Van Etta, L.L., Walker, D.H., Human granulocytic ehrlichiosis in the upper midwest United States. A new species emerging? (1994) Journal of the American Medical Association, 272, pp. 212-218

[3]

Johansson, K.E., Pettersson, B., Uhlen, M., Gunnarsson, A., Malmqvist, M., Olsson, E., Identification of the causative agent of granulocytic ehrlichiosis in Swedish dogs and horses by direct solid phase sequencing of PCR products from 16 S rRNA gene (1995) Research in Veterinary Science, 58, pp. 109-112

[4]

Brouqui, P., Dumler, J.S., Lienhard, R., Brossard, M., Raoult, D., Human granulocytic ehrlichiosis in Europe (1995) Lancet, 346, pp. 782-783

[5]

Sumption, K.J., Wright, D.J.M., Cutler, S.J., Dale, B.A.S., Human ehrlichiosis in the UK (1995) Lancet, 346, pp. 1487-1488

[6]

Bakken, J.S., Krueth, J., Tilden, R.L., Dumler, J.S., Kristiansen, B.E., Serological evidence of human granulocytic ehrlichiosis in Norway (1996) European Journal of Clinical Microbiology & Infectious Diseases, 15, pp. 829-832

[7]

Dumler, J.S., Dotevall, L., Gustafson, R., Granström, M., A population-based seroepidemiological study of human granulocytic ehrlichiosis (HGE) and Lyme borreliosis (LB) on the west coast of Sweden (1997) Journal of Infectious Diseases, 175, pp. 720-722

[8]

Fingerle, V., Goodman, J.L., Johnson, R.C., Kurtti, T.J., Munderloh, U.G., Wilske, B., Human granulocytic ehrlichiosis in southern Germany: Increased seroprevalence in high-risk groups (1997) Journal of Clinical Microbiology, 35, pp. 3244-3247

[9]

Hunfeld, K.P., Schulze, J., Brade, V., Mikrobiologische diagnostik der Lyme-Borreliose (1998) Lyme-Borreliose und Frühsommer-Meningoencephalitis, pp. 76-100. , Oschmann P, Kraiczy P (eds). Uni-Med Verlag, Bremen

[10]

Hunfeld, K.P., Allwinn, R., Albert, S., Schumm-Draeger, P.M., Brade, V., Doerr, H.W., Serologically proven double infection with tick-borne encephalitis virus (TBEV) and Borrelia burgdorferi (1998) Journal of Laboratory Medicine, 22, pp. 409-413

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