Thrombophilia in patients with hypertriglyceridemia

被引：15

作者：

Chan P. ^{[1
,5
]}

Huang T.-Y. ^{[2
]}

Shieh S.-M. ^{[3
]}

Lin T.-S. ^{[4
]}

Tsai C.-W. ^{[4
]}

机构：

[1] Department of Medicine, Taipei Medical College, Taipei Wang Fang Hospital, Taipei

[2] Department of Medicine, Chi-Mei Found. Hospital at Tainan, Taipei

[3] Department of Medicine, National Defense Medical College, Taipei

[4] Department of Medicine, Taipei Munic. Chung-Hsiao Hospital, Taipei

[5] Department of Medicine, Taipei Medical College, Taipei Wang Fang Hospital, Wen Shan, Taipei, 117, No. 111, Hsin Lung Road

来源：

Journal of Thrombosis and Thrombolysis | 1997年 / 4卷 / 3-4期

关键词：

Coagulation factors; Coronary heart disease; Hypertriglyceridemia;

D O I：

10.1023/A:1008857618659

中图分类号：

学科分类号：

摘要：

Objectives: To investigate a possible relationship between hypertriglyceridemia and the coagulation system, a Cardiovascular Risk Factor Two-township Study was conducted in Taiwan. Design: A case-control study. This longitudinal, prospective study focused on the evolution of cardiovascular disease risk factors with emphasis on haemostatic factors. Subjects: Hypertriglyceridemic subjects (triglyceride > 2.26 mmoll-1, n = 327) and age-matched normal controls from a population screening program. Main outcome measures: Haemostatic parameters measured in this study included prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, factors VIIc and VIIIc, and antithrombin-III and plasminogen levels. Results: In our male hypertriglyceridemic subjects, aPTT was not significantly reduced, while significant elevations of factor VIIIc, factor VIIc, and plasminogen and antithrombin-III levels were noted. In the female hypertriglyceridemic subjects, the elevation of factor VIIc, factor VIIIc, and plasminogen and antithrombin-III levels was highly-significant, whereas aPTT was not significantly reduced. Unexpectedly, the levels of the established coronary risk factor, fibrinogen, did not show a statistically different change. Similar to previous data, our hypertriglyceridemic subjects also presented with hyperinsulinemia, glucose intolerance, upper body obesity, and elevated blood pressure. Conclusions: Despite the fact that in population studies, triglycerides do not consistently appear to be an independent risk factor for coronary heart disease, our data suggest that a pronounced increase in triglycerides warrants aggressive therapy, because this increase may be associated with a hypercoagulable state. This phenomenon contributes another perspective to the study of higher cardiovascular mortality in hypertriglyceridemic subjects.

引用

页码：425 / 429

页数：4

共 38 条

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