The Influence of an Electret-Generated Electric Field Based on a Tantalum Oxide Anode on Differentiation Properties of Bone Marrow Stromal Cells from Patients with Osteoarthritis

被引：3

作者：

Aleksandrova S.A. ^{[1
]}

Aleksandrova O.I. ^{[1
]}

Khomutov V.P. ^{[2
]}

Morgunov M.S. ^{[2
]}

Blinova M.I. ^{[1
]}

机构：

[1] Institute of Cytology, Russian Academy of Sciences, Russian Academy of Sciences, St. Petersburg

[2] LLC Medel, St. Petersburg

来源：

Cell and Tissue Biology | 2019年 / 13卷 / 2期

关键词：

chondrogenic differentiation; electrets; multipotent mesenchymal stromal cells; osteoarthritis; osteogenic differentiation;

D O I：

10.1134/S1990519X19020020

中图分类号：

学科分类号：

摘要：

Abstract: The ability of the bone marrow multipotent mesenchymal stromal cells (MMSCs) of a patient with osteoarthritis to differentiate into the osteogenic and chondrogenic lineages under the influence of an electret-generated electric field created on the surface of anodic tantalum oxide was investigated. It has been shown that the synthesis of protein-differentiation markers in MMSCs is intensified in the presence of samples with anodic oxide in the electret state. The effect of electrets with uniform charge distribution over the surface was compared with linear charge distribution, MMSCs osteogenic differentiation was accompanied with enhanced expression of osteocalcin and type I collagen. These features were exhibited much stronger in cells exposed to electret specimens with a charge distribution on the surface close to linear. © 2019, Pleiades Publishing, Ltd.

引用

页码：144 / 151

页数：7

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