Central and peripheral sensitization in tension-type headache

被引：31

作者：

Lars Bendtsen

机构：

[1] Danish Headache Center, University of Copenhagen, Glostrup University Hospital, DK-2600 Glostrup, Copenhagen

来源：

Current Pain and Headache Reports | 2003年 / 7卷 / 6期

关键词：

Central Sensitization; Myofascial Pain; Type Headache; Pressure Pain Threshold; Peripheral Sensitization;

D O I：

10.1007/s11916-003-0062-9

中图分类号：

学科分类号：

摘要：

Recent studies on tension-type headache indicate that the nociceptive input to the central nervous system may be increased as a result of activation or sensitization of peripheral sensory afferents. Moreover, pain perception studies and pharmacologic studies strongly suggest that the central nervous system is sensitized in patients with chronic tension-type headache. The barrage of nociceptive impulses from the periphery may be responsible for the sensitization of second-and third-order neurons in the central nervous system. In this way, sensitization may play a role in the initiation and maintenance of tension-type headache. Studies have demonstrated that treatment with drugs that counteract sensitization has an analgesic effect on tension-type headache. Targeting this mode of action seems to be a promising way of improving the treatment for this prevalent disorder. Copyright © 2003 by Current Science Inc.

引用

页码：460 / 465

页数：5

共 39 条

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