Handgrip performance in relation to self-perceived fatigue, physical functioning and circulating IL-6 in elderly persons without inflammation

被引：89

作者：

Bautmans I. ^{[1
,2
]}

Gorus E. ^{[1
]}

Njemini R. ^{[1
]}

Mets T. ^{[1
,3
]}

机构：

[1] Gerontology, Free University of Brussels (VUB), B-1090 Brussels

[2] Rehabilitation Sciences and Physical Therapy, Free University of Brussels (VUB), B-1090 Brussels

[3] Geriatrics, University Hospital of the Free University of Brussels (UZ-VUB), B-1090 Brussels

来源：

BMC Geriatrics | / 7卷 / 1期

关键词：

Grip Strength; Fatigue Resistance; Muscle Performance; Normal Cognitive Function; Maximal Grip Strength;

D O I：

10.1186/1471-2318-7-5

中图分类号：

学科分类号：

摘要：

Background. Low grip strength is recognized as one of the characteristics of frailty, as are systemic inflammation and the sensation of fatigue. Contrary to maximal grip strength, the physical resistance of the muscles to fatigue is not often included in the clinical evaluation of elderly patients. The aim of this study was to investigate if the grip strength and the resistance of the handgrip muscles to fatigue are related to self-perceived fatigue, physical functioning and circulating IL-6 in independently living elderly persons. Methods. Forty elderly subjects (15 female and 25 male, mean age 75 ± 5 years) were assessed for maximal grip strength, as well as for fatigue resistance and grip work (respectively time and work delivered until grip strength drops to 50% of its maximum during sustained contraction), self perceived fatigue (VAS-Fatigue, Mob-Tiredness scale and the energy & fatigue items of the WHOQOL-100), self rated physical functioning (domain of physical functioning on the MOS short-form) and circulating IL-6. Relationships between handgrip performance and the other outcome measures were assessed. Results. In the male participants, fatigue resistance was negatively related to actual sensation of fatigue (VAS-F, p <.05) and positively to circulating IL-6 (p <.05). When corrected for body weight, the relations of fatigue resistance with self-perceived fatigue became stronger and also apparent in the female. Grip strength and grip work were significantly related with several items of self-perceived fatigue and with physical functioning. These relations became more visible by means of higher correlation coefficients when grip strength and grip work were corrected for body weight. Conclusion. Well functioning elderly subjects presenting less handmuscle fatigue resistance and weaker grip strength are more fatigued, experience more tiredness during daily activities and are more bothered by fatigue sensations. Body weight seems to play an important role in the relation of muscle performance to fatigue perception. Elderly patients complaining from fatigue should be physically assessed, both evaluating maximal grip strength and fatigue resistance, allowing the calculation of grip work, which integrates both parameters. Grip work might best reflect the functional capacity resulting from the development of a certain strength level in relation to the time it can be maintained. © 2007 Bautmans et al; licensee BioMed Central Ltd.

引用

共 37 条

[1] Rosenberg I.H., Sarcopenia: Origins and clinical relevance, J Nutr, 127, (1997)
[2] Merkies I.S., Schmitz P.I., Samijn J.P., Meche F.G., Toyka K.V., Van Doorn P.A., Assessing grip strength in healthy individuals and patients with immune-mediated polyneuropathies, Muscle Nerve, 23, pp. 1393-1401, (2000)
[3] Lauretani F., Russo C.R., Bandinelli S., Bartali B., Cavazzini C., Di Iorio A., Corsi A.M., Rantanen T., Guralnik J.M., Ferrucci L., Age-associated changes in skeletal muscles and their effect on mobility: An operational diagnosis of sarcopenia, J Appl Physiol, 95, pp. 1851-1860, (2003)
[4] Fried L.P., Tangen C.M., Walston J., Newman A.B., Hirsch C., Gottdiener J., Seeman T., Tracy R., Kop W.J., Burke G., McBurnie M.A., Frailty in Older Adults: Evidence for a Phenotype, J Gerontol a Biol Sci Med Sci, 56, pp. 146-157, (2001)
[5] Bautmans I., Njemini R., Lambert M., Demanet C., Mets T., Circulating Acute Phase Mediators and Skeletal Muscle Performance in Hospitalized Geriatric Patients, J Gerontol a Biol Sci Med Sci, 60, pp. 361-367, (2005)
[6] Visser M., Pahor M., Taaffe D.R., Goodpaster B.H., Simonsick E.M., Newman A.B., Nevitt M., Harris T.B., Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: The Health ABC Study, J Gerontol a Biol Sci Med Sci, 57, pp. 326-32, (2002)
[7] Bruunsgaard H., Pedersen B.K., Age-related inflammatory cytokines and disease, Immunol Allergy Clin North Am, 23, pp. 15-39, (2003)
[8] Metter E.J., Talbot L.A., Schrager M., Conwit R., Skeletal Muscle Strength as a Predictor of All-Cause Mortality in Healthy Men, J Gerontol a Biol Sci Med Sci, 57, pp. 359-365, (2002)
[9] Rantanen T., Guralnik J.M., Foley D., Masaki K., Leveille S., Curb J.D., White L., Midlife hand grip strength as a predictor of old age disability, Jama, 281, pp. 558-560, (1999)
[10] Syddall H., Cooper C., Martin F., Briggs R., Aihie Sayer A., Is grip strength a useful single marker of frailty?, Age Ageing, 32, pp. 650-656, (2003)

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