Landiolol attenuates the cardiovascular response to tracheal intubation

被引：25

作者：

Goyagi T. ^{[1
]}

Tanaka M. ^{[1
]}

Nishikawa T. ^{[1
]}

机构：

[1] Department of Anesthesiology, Akita University, School of Medicine, Akita 010-8543

来源：

Journal of Anesthesia | 2005年 / 19卷 / 4期

关键词：

Hemodynamics; Intubation; Landiolol;

D O I：

10.1007/s00540-005-0347-8

中图分类号：

学科分类号：

摘要：

Purpose: The objective of this prospective study was to compare the cardiovascular responses with or without landiolol to the induction of general anesthesia and tracheal intubation. Methods: Twenty-two patients were randomly allocated to receive a loading dose of landiolol 125μg kg-1min-1 for 1min followed by an infusion at 40μg kg-1min-1 for 4min, or placebo. Four minutes after landiolol or placebo was started, propofol and succinylcholine were administered. Laryngoscopy and tracheal intubation were performed 1min after the administration of succinylcholine. Heart rate and blood pressure were measured noninvasively every minute. Results: A significant attenuation of the heart rate and blood pressure response were seen in the landiolol group for 3min after intubation. Heart rate and systolic blood pressure in the landiolol group were decreased for 2min before intubation and just before intubation compared with baseline, srespectively. Conclusion: Continuous administration of landiolol before tracheal intubation results in the attenuation of cardiovascular response for tracheal intubation. © JSA 2005.

引用

页码：282 / 286

页数：4

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