Alterated integrin expression in lichen planopilaris

被引：9

作者：

D'Ovidio R. ^{[1
]}

Sgarra C. ^{[2
]}

Conserva A. ^{[3
]}

Angelotti U.F. ^{[2
]}

Erriquez R. ^{[2
]}

Foti C. ^{[3
]}

机构：

[1] AIDA/Tricologia, Bari

[2] Department of Internal Medicine, Immunology and Infectious Diseases, Unit of Internal Medicine, University of Bari, 70124 Bari

[3] Department of Internal Medicine, Immunology and Infectious Diseases, Unit of Dermatology, University of Bari, 70124 Bari

来源：

Head & Face Medicine | / 3卷 / 1期

关键词：

Hair Follicle; Outer Root Sheath; Basement Membrane Component; Scalp Skin; Outer Root Sheath Cell;

D O I：

10.1186/1746-160X-3-11

中图分类号：

学科分类号：

摘要：

Background: Lichen planopilaris (LPP) is an inflammatory disease characterized by a lymphomononuclear infiltrate surrounding the isthmus and infundibulum of the hair follicle of the scalp, that evolves into atrophic/scarring alopecia. In the active phase of the disease hairs are easily plucked with anagen-like hair-roots. In this study we focused on the expression of integrins and basement membrane components of the hair follicle in active LPP lesions. Methods: Scalp biopsies were taken in 10 patients with LPP and in 5 normal controls. Using monoclonal antibodies against α3β 1, and α6β4 integrins we showed the expression of these integrins and of the basement membrane components of the hair follicle in active LPP lesions and in healthy scalp skin. Results: In the LPP involved areas, α3β1, was distributed in a pericellular pattern, the α6 subunit was present with a basolateral distribution while the β4 subunit showed discontinuous expression at the basal pole and occasionally, basolateral staining of the hair follicle. Conclusion: An altered distribution of the integrins in active LPP lesions can explain the phenomenon of easy pulling-out of the hair with a gelatinous" root-sheath."

引用

共 12 条

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[2]

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[3]

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[8]

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[9]

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[10]

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