Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents

被引：141

作者：

Chel V. ^{[1
,2
]}

Wijnhoven H.A.H. ^{[2
]}

Smit J.H. ^{[3
]}

Ooms M. ^{[2
]}

Lips P. ^{[2
,4
]}

机构：

[1] Verpleeghuis Marienhave, Warmond

[2] EMGO Institute, VU University Medical Center, Amsterdam

[3] Department of Psychiatry, VU University Medical Center, Amsterdam

[4] Department of Endocrinology, VU University Medical Center, Amsterdam 1007 MB

来源：

Osteoporosis International | 2008年 / 19卷 / 5期

关键词：

Calcium supplementation; Secondary hyperparathyroidism; Vitamin D deficiency; Vitamin D supplementation;

D O I：

10.1007/s00198-007-0465-2

中图分类号：

学科分类号：

摘要：

Summary: The effect of equivalent oral doses of vitamin D3 600 IU/day, 4200 IU/week and 18,000 IU/month on vitamin D status was compared in a randomized clinical trial in nursing home residents. A daily dose was more effective than a weekly dose, and a monthly dose was the least effective. Introduction: It is assumed that equivalent daily, weekly or monthly doses of vitamin D3 equally influence vitamin D status. This was investigated in a randomized clinical trial in nursing home residents. Methods: The study was performed in ten nursing homes including 338 subjects (76 male and 262 female), with a mean age of 84 (± SD 6.3 years). They received oral vitamin D3 either 600 IU/day, or 4200 IU/week, or 18,000 IU/month or placebo. After 4 months, calcium was added during 2 weeks, 320 mg/day or 640 mg/day or placebo. Outcome: serum levels of 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and bone turnover markers. Statistical approach: linear multilevel analysis. Results: At baseline, mean serum 25(OH)D was 25.0 nmol/L (SD 10.9), and in 98%, it was lower than 50 nmol/L. After 4 months, mean serum 25(OH)D levels increased to 62.5 nmol/L (after daily vitamin D3 69.9 nmol/L, weekly 67.2 nmol/L and monthly 53.1 nmol/L, P<0.001 between groups). Median serum PTH levels decreased by 23% (p<0.001). Bone turnover markers did not decrease. Calcium supplementation had no effect on serum PTH and bone turnover. Conclusion: Daily vitamin D was more effective than weekly, and monthly administration was the least effective. © 2007 International Osteoporosis Foundation and National Osteoporosis Foundation.

引用

页码：663 / 671

页数：8

共 27 条

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