The Cardioprotective Agent Urocortin Induces Expression of CT-1

被引：21

作者：

Sadia Janjua

Kevin M. Lawrence

Leong L. Ng

David S. Latchman

机构：

[1] Institute of Child Health, University College London

[2] Department of Medicine, University of Leicester, Leicester Royal Infirmary

来源：

Cardiovascular Toxicology | 2003年 / 3卷 / 3期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Cardioprotection; Cardiotrophin-1; Gene regulation; Interleukin-6 family cytokines; Urocortin;

D O I：

10.1385/CT:3:3:255

中图分类号：

学科分类号：

摘要：

The corticotrophin-releasing hormone-related factor, urocortin (Ucn) and the interleukin (IL)-6 family cytokine cardiotrophin-1 (CT-1) are both cardioprotective agents able to protect the heart from ischemic damage. In both cases the protective effect involves activation of the p42/p44 MAPK and PI-3 kinase/Akt pathways, but the protective effect of Ucn requires de novo protein synthesis whereas that of CT-1 does not. In this study, we show that Ucn induces enhanced expression of CT-1 at both the mRNA and protein levels. This effect is mediated by activation of the CT-1 gene promoter and requires the transcription factor C/EBPβ/NF-IL6. Hence, a specific cardioprotective factor can induce enhanced expression of another cardioprotective factor belonging to an unrelated protein family.

引用

页码：255 / 261

页数：6

共 24 条

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