Yeast and drug discovery

被引：70

作者：

Hughes T.R. ^{[1
]}

机构：

[1] Banting and Best Department of Medical Research, University of Toronto, Toronto, Ont. M5G 1L6

来源：

Functional & Integrative Genomics | 2002年 / 2卷 / 4-5期

关键词：

Drug discovery; High-throughput screening; Pharmaceutical industry; Yeast;

D O I：

10.1007/s10142-002-0059-1

中图分类号：

学科分类号：

摘要：

Advanced genetic techniques, along with the high degree of conservation of basic cellular processes, have made the yeast Saccharomyces cerevisiae a valuable system for identification of new drug targets, target-based and non-target-based drug screening, and detailed analysis of the cellular effects of drugs. Yeast also presents a convenient system for antifungal drug discovery because it is closely related to Candida albicans, a major human pathogen. Many yeast genes remain poorly characterized, and most of the sophisticated techniques in yeast have been in widespread use less than a decade - a period shorter than the typical cycle from target identification to marketing approval for a new drug. It is likely that most of the benefits of yeast in discovery and development of therapeutic compounds have yet to be realized. © Springer-Verlag 2002.

引用

页码：199 / 211

页数：12

共 124 条

[1]

Anderson J.A., Huprikar S.S., Kochian L.V., Lucas W.J., Gaber R.F., Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae, Proc Natl Acad Sci USA, 89, pp. 3736-3740, (1992)

[2]

Aucott J.N., Et al., Invasive infection with Saccharomyces cerevisiae: Report of three cases and review, Rev Infect Dis, 12, pp. 406-411, (1990)

[3]

Bach T.J., Lichtenthaler H.K., Mechanisms of inhibition by mevinolin (MK 803) of microsome-bound radish and of partially purified yeast HMG-CoA reductase (EC.1.1.1.34), Z Naturforsch, 38, pp. 212-219, (1983)

[4]

Barnes G., Hansen W.J., Holcomb C.L., Rine J., Asparagine-linked glycosylation in Saccharomyces cerevisiae: Genetic analysis of an early step, Mol Cell Biol, 4, pp. 2381-2388, (1984)

[5]

Barns S.M., Lane D.J., Sogin M.L., Bibeau C., Weisburg W.G., Evolutionary relationships among pathogenic Candida species and relatives, J Bacteriol, 173, pp. 2250-2255, (1991)

[6]

Bassett Jr. D.E., Et al., Genome cross-referencing and XREFdb: Implications for the identification and analysis of genes mutated in human disease, Nat Genet, 15, pp. 339-344, (1997)

[7]

Bedalov A., Gatbonton T., Irvine W.P., Gottschling D.E., Simon J.A., Identification of a small molecule inhibitor of Sir2p, Proc Natl Acad Sci USA, 98, pp. 15113-15118, (2001)

[8]

Bennett R.J., Noirot-Gros M.F., Wang J.C., Interaction between yeast sgs1 helicase and DNA topoisomerase III, J Biol Chem, 275, pp. 26898-26905, (2000)

[9]

Botstein D., Chervitz S.A., Cherry J.M., Yeast as a model organism, Science, 277, pp. 1259-1260, (1997)

[10]

Brenner C., A cultivated taste for yeast, Genome Biol, 1, (2000)

← 1 2 3 4 5 6 7 8 9 10 →