Hypertriglyceridemia and risk of coronary heart disease

被引：47

作者：

Hokanson J.E. ^{[1
]}

机构：

[1] Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262

来源：

Current Cardiology Reports | 2002年 / 4卷 / 6期

关键词：

Triglyceride; Familial Combine Hyperlipidemia; Lipoprotein Lipase Gene; Lipoprotein Lipase Deficiency; Paris Prospective Study;

D O I：

10.1007/s11886-002-0112-7

中图分类号：

学科分类号：

摘要：

Mounting evidence indicates that elevated triglyceride level is a risk factor for coronary heart disease (CHD). The role of triglyceride as a causative agent for CHD is less clear. Hypertriglyceridemia is frequently associated with a set of complex metabolic abnormalities, including low high-density lipoprotein cholesterol, small dense low-density lipoprotein, central obesity, insulin resistance, and type 2 diabetes. Understanding the physiologic processes that lead to the metabolic disturbances associated with hypertriglyceridemia is essential in investigating the effect of triglyceride on CHD risk. Copyright © 2002 by Current Science Inc.

引用

页码：488 / 493

页数：5

共 28 条

[1] Gofman J.W., Delalla O., Flazier F., Et al., The serum lipoprotein transport system in health, metabolic disorders, atherosclerosis, and coronary disease, Plasma, 2, pp. 413-483, (1954)
[2] Albrink M., Mann E., Serum triglycerides in coronary artery disease, Arch Intern Med, 103, pp. 4-8, (1959)
[3] Brown D.F., Kinch S.H., Doyle J.T., Serum triglycerides in health and in ischemic heart disease, N Engl J Med, 273, pp. 947-952, (1965)
[4] Hulley S.B., Rosenman R.H., Bawol R.D., Brand R.J., Epidemiology as a guide to clinical decisions. The association between triglyceride and coronary heart disease, N Engl J Med, 302, pp. 1383-1389, (1980)
[5] Hokanson J.E., Austin M.A., Plasma triglyceride is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: A meta-analysis of populationbased prospective studies, J Cardiovasc Risk, 3, pp. 213-219, (1996)
[6] Abdel-Maksoud M.F., Hokanson J.E., The complex role of triglyceride in cardiovascular disease: Both independence and synergy with hdl cholesterol, Semin Vasc Med, 2, pp. 325-333, (2002)
[7] Jeppesen J., Hein H.O., Suadicani P., Gyntelberg F., Triglyceride concentration and ischemic heart disease: An eight-year follow-up in the copenhagen male study, Circulation, 97, pp. 1029-1036, (1998)
[8] Assmann G., Schulte H., Funke H., Von Eckardstein A., The emergence of triglycerides as a significant independent risk factor in coronary artery disease, Eur Heart J, 19, SUPPL. M, (1998)
[9] Onat A., Sansoy V., Yildirim B., Which fasting triglyceride levels best reflect coronary risk? evidence from the turkish adult risk factor study, Clin Cardiol, 24, pp. 9-14, (2001)
[10] Cambien F., Jacqueson A., Richard J.L., Et al., Is the level of serum triglyceride a significant predictor of coronary death in "normocholesterolemic" subjects? The paris prospective study, Am J Epidemiol, 124, pp. 624-632, (1986)

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