Systematic review and network meta-analysis of interventions for fibromyalgia: a protocol.

被引：16

作者：

Busse J.W. ^{[1
]}

Ebrahim S. ^{[1
]}

Connell G. ^{[1
]}

Coomes E.A. ^{[1
]}

Bruno P. ^{[1
]}

Malik K. ^{[1
]}

Torrance D. ^{[1
]}

Ngo T. ^{[1
]}

Kirmayr K. ^{[1
]}

Avrahami D. ^{[1
]}

Riva J.J. ^{[1
]}

Struijs P. ^{[1
]}

Brunarski D. ^{[1
]}

Burnie S.J. ^{[1
]}

LeBlanc F. ^{[1
]}

Steenstra I.A. ^{[1
]}

Mahood Q. ^{[1
]}

Thorlund K. ^{[1
]}

Montori V.M. ^{[1
]}

Sivarajah V. ^{[1
]}

Alexander P. ^{[1
]}

Jankowski M. ^{[1
]}

Lesniak W. ^{[1
]}

Faulhaber M. ^{[1
]}

Bała M.M. ^{[1
]}

Schandelmaier S. ^{[1
]}

Guyatt G.H. ^{[1
]}

机构：

[1] Department of Anesthesia, McMaster University, 1200 Main Street West, L8S 4K1, Hamilton, Ontario

来源：

Systematic Reviews | / 2卷 / 1期

关键词：

Fibromyalgia; Systematic review; Network meta-analysis; Multiple treatment comparison; Randomized controlled trials;

D O I：

10.1186/2046-4053-2-18

中图分类号：

学科分类号：

摘要：

Fibromyalgia is associated with substantial socioeconomic loss and, despite considerable research including numerous randomized controlled trials (RCTs) and systematic reviews, there exists uncertainty regarding what treatments are effective. No review has evaluated all interventional studies for fibromyalgia, which limits attempts to make inferences regarding the relative effectiveness of treatments. We will conduct a network meta-analysis of all RCTs evaluating therapies for fibromyalgia to determine which therapies show evidence of effectiveness, and the relative effectiveness of these treatments. We will acquire eligible studies through a systematic search of CINAHL, EMBASE, MEDLINE, AMED, HealthSTAR, PsychINFO, PapersFirst, ProceedingsFirst, and the Cochrane Central Registry of Controlled Trials. Eligible studies will randomly allocate patients presenting with fibromyalgia or a related condition to an intervention or a control. Teams of reviewers will, independently and in duplicate, screen titles and abstracts and complete full text reviews to determine eligibility, and subsequently perform data abstraction and assess risk of bias of eligible trials. We will conduct meta-analyses to establish the effect of all reported therapies on patient-important outcomes when possible. To assess relative effects of treatments, we will construct a random effects model within the Bayesian framework using Markov chain Monte Carlo methods. Our review will be the first to evaluate all treatments for fibromyalgia, provide relative effectiveness of treatments, and prioritize patient-important outcomes with a focus on functional gains. Our review will facilitate evidence-based management of patients with fibromyalgia, identify key areas for future research, and provide a framework for conducting large systematic reviews involving indirect comparisons.

引用

共 656 条

[1]

Wolfe F(1990)The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee Arthritis Rheum 33 160-172

[2]

Smythe HA(1995)The prevalence and characteristics of fibromyalgia in the general population Arthritis Rheum 38 19-28

[3]

Yunus MB(2009)Prevalence of fibromyalgia in a low socioeconomic status population BMC Musculoskelet Disord 10 64-453

[4]

Bennett RM(2010)Prevalence of fibromyalgia: a survey in five European countries Semin Arthritis Rheum 39 448-1045

[5]

Bombardier C(2001)The burden of musculoskeletal diseases in the general population of Spain: results from a national survey Ann Rheum Dis 60 1040-610

[6]

Goldenberg DL(2008)Chronic widespread musculoskeletal pain. A comparison of those who meet criteria for fibromyalgia and those who do not Eur J Pain 12 600-828

[7]

Tugwell P(2005)Prevalence of musculoskeletal conditions in an Italian population sample: results of a regional community-based study. I. The MAPPING study Clin Exp Rheumatol 23 819-1576

[8]

Campbell SM(1999)The London Fibromyalgia Epidemiology Study: the prevalence of fibromyalgia syndrome in London, Ontario J Rheumatol 26 1570-9

[9]

Abeles M(2003)Prospective epidemiological observations on the course of the disease in fibromyalgia patients J Negat Results Biomed 2 4-1579

[10]

Clark P(1997)Health status and disease severity in fibromyalgia: results of a six-center longitudinal study Arthritis Rheum 40 1571-142

← 1 2 3 4 5 6 7 8 9 10 →