Rapid N-acetyltransferase 2 imputed phenotype and smoking may increase risk of colorectal cancer in women (Netherlands)

被引：23

作者：

Olga L. van der Hel

H. Bas Bueno de Mesquita

Lodewijk Sandkuijl

Paul A.H. van Noord

Peter L. Pearson

Diederick E. Grobbee

Petra H.M. Peeters

机构：

[1] Julius Ctr. Hlth. Sci./Prim. Care, University Medical Centre, Utrecht

[2] Dept. of Chron. Dis. Epidemiology, Natl. Inst. Pub. Hlth./Environ.

[3] Department of Medical Genetics, University Medical Centre, Utrecht

[4] Julius Ctr. Hlth. Sci./Prim. Care, University Medical Centre, 3508 GA Utrecht

来源：

Cancer Causes & Control | 2003年 / 14卷 / 3期

关键词：

Colorectal cancer; N-acetyltransferase; 2; Prospective study; Smoking; Women;

D O I：

10.1023/A:1023601922106

中图分类号：

学科分类号：

摘要：

Objective: The relationship between smoking and colorectal cancer risk and whether such effect is modified by variations in the NAT2 genotype is investigated. Methods: In the prospective DOM (Diagnostisch Onderzoek Mammacarcinoom; 27,722 women) cohort follow-up from 1976 until 1987 revealed 54 deaths due to colon or rectal cancer, and follow-up from 1987 to 01-01-1996 revealed 204 incident colorectal cancer cases. A random sample (n = 857) from the baseline cohort was used as controls. Four NAT2 restriction fragment length polymorphisms (RFLPs) were analysed using DNA extracted from urine samples. Rapid or slow acetylator phenotype status was attributed to individuals. Results: Smoking may increase the risk for colon cancer (RR = 1.36, 95% CI 0.97-1.92) as well as for rectal cancer (RR = 1.31, 95% CI 0.76-2.25), although not statistically significant. Rapid NAT2 acetylation did not increase colorectal cancer risk, but in combination with smoking the risk was statistically significant increased, compared to women who had a slow NAT2 imputed phenotype and never smoked (RR = 1.56, 95% CI 1.03-2.37). For colon cancer, but not for rectal cancer the increased risk was statistically significant (RR = 1.67, 95% CI, 1.05-2.67 versus RR = 1.30 95% CI 0.63-2.68). Conclusions: Our study points to smoking as a risk factor for colon and rectal cancer and, in addition, especially in women with rapid NAT2 imputed phenotype.

引用

页码：293 / 298

页数：5

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