Discovery and development of anti-angiogenic peptides: A structural link

被引：24

作者：

Ruud P.M. Dings

Irina Nesmelova

Arjan W. Griffioen

Kevin H. Mayo

机构：

[1] Dept. Biochem., Molec. Bio./Biophys., Univ. of Minnesota Hlth. Sci. Center, Minneapolis, MN

[2] Department of Internal Medicine, University Hospital, Maastricht University, Maastricht

[3] Dept. Biochem., Molec. Bio./Biophys., Univ. of Minnesota Hlth. Sci. Center, Minneapolis, MN 55455

来源：

Angiogenesis | 2003年 / 6卷 / 2期

基金：

美国国家卫生研究院;

关键词：

Angiogenesis inhibition; Angiostatic peptides; Angiostatic proteins; Designer peptides and review;

D O I：

10.1023/B:AGEN.0000011730.94233.06

中图分类号：

学科分类号：

摘要：

Cancer is a disease promoted by excess angiogenesis. Interference with this process poses an attractive approach to controling aberrant tumor growth, a hypothesis first proposed in the early 1970s that led to world-wide focus on identifying and developing angiogenesis inhibitors, which currently number in the hundreds. This review surveys the discovery and development of anti-angiogenic protein fragments and peptides, with a slant towards understanding their structure-function relationships to aid in the design of better therapeutic agents.

引用

页码：83 / 91

页数：8

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